ArticleBiology2020
Design and Characterization of a Minimally Invasive Bipolar Electrode for Electroporation.
Article in Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Bipolar needle electrodes for electroporation-based treatments in soft and bone tissues: technical design and implementation.La Radiologia medica · 2026Article
- Transdermal needle-free drug delivery approaches and activation mechanism.Materials today. Bio · 2026Review
- The use of a bipolar single-needle electrode for electrochemotherapy combined with gene electrotransfer of IL-12 in a mast cell tumor on the nasal planum of a dog: case report.Frontiers in veterinary science · 2026Article
- Custom bipolar electrode for bleomycin-based electrochemotherapy in patient-derived uveal melanomaFrontiers in cell and developmental biology · 2026Article
- Application of a new coaxial bipolar electrode for the treatment of vertebral metastases: a pilot study in an ovine model.Frontiers in medicine · 2025Article
- Computer modelling and vegetable bench test of a bipolar electrode array intended for use in high frequency irreversible electroporation treatment of skin cancer.Biomedical engineering letters · 2025Article
- The Effect of Discharge Mode on the Distribution of Myocardial Pulsed Electric Field-A Simulation Study for Pulsed Field Ablation of Atrial Fibrillation.Journal of cardiovascular development and disease · 2022Article
- Evaluation of electroporated area using 2,3,5-triphenyltetrazolium chloride in a potato model.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo test a new bipolar electrode for electroporation consisting of a single minimally invasive needle.
methodsA theoretical study was performed by using Comsol Multiphysics
resultsSimulations and pre-clinical tests have shown that the volume of ablated area is mainly influenced by applied voltage, while the diameter of the electrode had a lesser impact, making the goal of minimal-invasiveness possible. The conductive pole's length determined an increase of electroporated volume, while the insulated pole length inversely affects the electroporated volume size and shape; when the insulated pole length decreases, a more regular shape of the electric field is obtained. Moreover, the geometry of the electrode determined a different shape of the electroporated volume. A parenchymal damage in the liver of pigs due to irreversible electroporation protocol was observed.
conclusionThe minimally invasive bipolar electrode is able to treat an electroporated volume of about 10 mm in diameter by using a single-needle electrode. Moreover, the geometry and the electric characteristics can be selected to produce ellipsoidal ablation volumes.
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Registered trials
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