Evidence map›Paper›PMID 32967238›Full record

ArticleInternational journal of molecular sciences2020

Interactions among Genetic Background, Anesthetic Agent, and Oxygen Concentration Shape Blunt Traumatic Brain Injury Outcomes in

Amanda R Scharenbrock, Hannah J Schiffman, Zachariah P G Olufs, David A Wassarman, Misha Perouansky

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amanda R ScharenbrockDepartment of Anesthesiology, University of Wisconsin-Madison, Madison, WI 53792, USA.
Hannah J SchiffmanDepartment of Anesthesiology, University of Wisconsin-Madison, Madison, WI 53792, USA.
Zachariah P G OlufsDepartment of Anesthesiology, University of Wisconsin-Madison, Madison, WI 53792, USA.
David A WassarmanDepartment of Medical Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA.
Misha PerouanskyDepartment of Anesthesiology, University of Wisconsin-Madison, Madison, WI 53792, USA.ORCID 0000-0003-1759-5277
University of Wisconsin–Madison · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
TBI and aging in a Drosophila modelRF1NS114359 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI WASSARMAN, DAVID · 2019 to 2019
$2.8M
Anesthetic-Induced Neurotoxicity: Molecular Pathways and Genetic Risk FactorsR01GM134107 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WASSARMAN, DAVID · 2020 to 2023
$1.4M
Department of Anesthesiology, University of Wisconsin-Madison Seed GrantInstitute for Clinical and Translational Research, University of Wisconsin, Madison 1UL1TR002373NCATS NIH HHS UL1 TR002373NIGMS NIH HHS R01 GM134107NIGMS NIH HHS R01GM134107NINDS NIH HHS RF1 NS114359
6 · The paper itself

Abstract

Following traumatic brain injury (TBI), the time window during which secondary injuries develop provides a window for therapeutic interventions. During this time, many TBI victims undergo exposure to hyperoxia and anesthetics. We investigated the effects of genetic background on the interaction of oxygen and volatile general anesthetics with brain pathophysiology after closed-head TBI in the fruit fly

Indexed as

Genetic BackgroundHead Injuries, ClosedHyperoxiaAnesthetics, InhalationAnimalsBrainBrain Injuries, TraumaticDisease Models, AnimalDrosophila melanogasterHumansIsofluraneOxygen ConsumptionSevofluraneAnesthetics, InhalationIsofluraneSevofluraneanesthesiaDrosophila melanogasterhyperoxiaisofluranepharmacogeneticssecondary injurysevofluraneTBI

Identifiers

PMID32967238
PMCPMC7555144
OpenAlexW3087090284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.