ArticleInternational journal of molecular sciences2020
Dim Light at Night Disturbs Molecular Pathways of Lipid Metabolism.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Impact of artificial light at night on obesity and overweight: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Chronic exposure to artificial light at night dampens rhythms in locomotor activity, metabolism, and sleep in female mice.Physiology & behavior · 2026Article
- Exposure to Dim Light at Night Impairs Photoperiodic and Metabolic Gene Expression in Syrian Hamsters (Mesocricetus auratus).Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Artificial Light at Night, Sleep Disruption, and Liver Health: Implications for MASLD Pathogenesis.International journal of environmental research and public health · 2025Review
- Naturalight: A controlled illuminated environment to study light exposure impact on behavior and cognition in freely moving rats.HardwareX · 2025Article
- Effect of gestational exposure to dim light at night on the behavior of rat dams and offspring.Scientific reports · 2025Article
- Article
- Lipid metabolic adaptations during inflammation are controlled by the circadian clock and impaired by light at night.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Outdoor artificial light-at-night and cardiometabolic disease risk: an urban perspective from the Catalan GCAT cohort study.American journal of epidemiology · 2025Article
- Impact of Long-Lasting Environmental Factors on Regulation Mediated by the miR-34 Family.Biomedicines · 2024Review
- Blue Light and Temperature Actigraphy Measures Predicting Metabolic Health Are Linked to Melatonin Receptor Polymorphism.Biology · 2023Article
- Review
- Exposure to dim light at night alters daily rhythms of glucose and lipid metabolism in rats.Frontiers in physiology · 2022Article
- Light at Night and Disrupted Circadian Rhythms Alter Physiology and Behavior.Integrative and comparative biology · 2021Review
- Dim Light at Night Impairs Daily Variation of Circulating Immune Cells and Renal Immune Homeostasis.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Dim light at night (dLAN) is associated with metabolic risk but the specific effects on lipid metabolism have only been evaluated to a limited extent. Therefore, to explore whether dLAN can compromise lipid metabolic homeostasis in healthy individuals, we exposed Wistar rats to dLAN (~2 lx) for 2 and 5 weeks and analyzed the main lipogenic pathways in the liver and epididymal fat pad, including the control mechanisms at the hormonal and molecular level. We found that dLAN promoted hepatic triacylglycerol accumulation, upregulated hepatic genes involved in de novo synthesis of fatty acids, and elevated glucose and fatty acid uptake. These observations were paralleled with suppressed fatty acid synthesis in the adipose tissue and altered plasma adipokine levels, indicating disturbed adipocyte metabolic function with a potential negative impact on liver metabolism. Moreover, dLAN-exposed rats displayed an elevated expression of two peroxisome proliferator-activated receptor family members (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.