Evidence map›Paper›PMID 32967146›Full record

Trial reportInternational journal of molecular sciences2020

Classifications of Neurodegenerative Disorders Using a Multiplex Blood Biomarkers-Based Machine Learning Model.

Chin-Hsien Lin, Shu-I Chiu, Ta-Fu Chen, Jyh-Shing Roger Jang, Ming-Jang Chiu

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.

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  8. Cognitive impairment in Parkinson's disease and other parkinsonian syndromes.Journal of neural transmission (Vienna, Austria : 1996) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chin-Hsien LinDepartment of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 100225, Taiwan.ORCID 0000-0001-8566-7573
Shu-I ChiuDepartment of Computer Science and Information Engineering, National Taiwan University, Taipei 10617, Taiwan.ORCID 0000-0001-8027-9686
Ta-Fu ChenDepartment of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 100225, Taiwan.ORCID 0000-0003-1988-6924
Jyh-Shing Roger JangDepartment of Computer Science and Information Engineering, National Taiwan University, Taipei 10617, Taiwan.
Ming-Jang ChiuDepartment of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 100225, Taiwan.ORCID 0000-0002-4158-4423
National Taiwan University · TWNational Taiwan University Hospital · TW

Funding

Ministry of Science and Technology, Taiwan MOST 06-2321- B002 -029
6 · The paper itself

Abstract

Easily accessible biomarkers for Alzheimer's disease (AD), Parkinson's disease (PD), frontotemporal dementia (FTD), and related neurodegenerative disorders are urgently needed in an aging society to assist early-stage diagnoses. In this study, we aimed to develop machine learning algorithms using the multiplex blood-based biomarkers to identify patients with different neurodegenerative diseases. Plasma samples (

Indexed as

Cognitive DysfunctionMachine LearningNeurodegenerative DiseasesAgedAged, 80 and overalpha-SynucleinAmyloid beta-PeptidesBiomarkersFemaleHumansMaleMiddle AgedPeptide Fragmentstau Proteinsalpha-SynucleinAmyloid beta-Peptidesamyloid beta-protein (1-40)amyloid beta-protein (1-42)BiomarkersMAPT protein, humanPeptide FragmentsSNCA protein, humantau ProteinsAlzheimer’s diseasebiomarkersclassificationdeep learning modelfrontotemporal dementialinear discriminant analysismultivariate imputation by chained equationsneurodegenerative disordersParkinson’s disease

Identifiers

PMID32967146
PMCPMC7555120
OpenAlexW3087092489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.