Evidence map›Paper›PMID 32966846›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2021

Rate of radiation-induced microbleed formation on 7T MRI relates to cognitive impairment in young patients treated with radiation therapy for a brain tumor.

Melanie A Morrison, Sabine Mueller, Erin Felton, Angela Jakary, Schuyler Stoller, Sivakami Avadiappan, Justin Yuan, Annette M Molinaro, Steve Braunstein, Anu Banerjee and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Melanie A MorrisonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, USA.
Sabine MuellerDepartment of Neurology, University of California San Francisco, USA.
Erin FeltonDepartment of Neurology, University of California San Francisco, USA.
Angela JakaryDepartment of Radiology and Biomedical Imaging, University of California San Francisco, USA.
Schuyler StollerDepartment of Neurology, University of California San Francisco, USA.
Sivakami AvadiappanDepartment of Radiology and Biomedical Imaging, University of California San Francisco, USA.
Justin YuanDepartment of Radiology and Biomedical Imaging, University of California San Francisco, USA.
Annette M MolinaroDepartment of Neurological Surgery, University of California San Francisco, USA; Department of Epidemiology & Biostatistics, University of California San Francisco, USA.
Steve BraunsteinDepartment of Radiation Oncology, University of California San Francisco, USA.
Anu BanerjeeDepartment of Neurology, University of California San Francisco, USA.
Christopher P HessDepartment of Radiology and Biomedical Imaging, University of California San Francisco, USA; Department of Neurology, University of California San Francisco, USA.
Janine M LupoDepartment of Radiology and Biomedical Imaging, University of California San Francisco, USA. Electronic address: janine.lupo@ucsf.edu.
University of California, San Francisco · US

Funding

MICROBLEEDS AS A MARKER OF RADIATION-INDUCED BRAIN INJURY IN PEDIATRIC PATIENTSR01HD079568 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LUPO, JANINE MARIE · 2015 to 2019
$2.5M
NICHD NIH HHS R01 HD079568
6 · The paper itself

Abstract

backgroundRadiation therapy (RT) is essential to the management of many brain tumors, but has been known to lead to cognitive decline and vascular injury in the form of cerebral microbleeds (CMBs). PURPOSE: In a subset of children, adolescents, and young adults recruited from a larger trial investigating arteriopathy and stroke risk after RT, we evaluated the prevalence of CMBs after RT, examined risk factors for CMBs and cognitive impairment, and related their longitudinal development to cognitive performance changes.

methodsTwenty-five patients (mean 17 years, range: 10-25 years) underwent 7-Tesla MRI and cognitive assessment. Nineteen patients were treated with whole-brain or focal RT 1-month to 20-years prior, while 6 non-irradiated patients with posterior-fossa tumors served as controls. CMBs were detected on 7T susceptibility-weighted imaging (SWI) using semi-automated software, a first use in this population.

resultsCMB detection sensitivity with 7T SWI was higher than previously reported at lower field strengths, with one or more CMBs detected in 100% of patients treated with RT at least 1-year prior. CMBs were localized to dose-targeted brain volumes with risk factors including whole-brain RT (p = 0.05), a higher RT dose (p = 0.01), increasing time since RT (p = 0.03), and younger age during RT (p = 0.01). Apart from RT dose, these factors were associated with impaired memory performance. Follow-up data in a subset of patients revealed a proportional increase in CMB count with worsening verbal memory performance (r = -0.85, p = 0.03).

conclusionsTreatment with RT during youth is associated with the chronic development of CMBs that evolve with memory impairment over time.

Indexed as

Brain NeoplasmsCognitive DysfunctionAdolescentBrainCerebral HemorrhageChildHumansMagnetic Resonance ImagingYoung AdultBrain tumorsCerebral microbleedsCognitive outcomeRadiation therapyUltra-high field magnetic resonance imaging

Identifiers

PMID32966846
PMCPMC8208731
OpenAlexW3087123386

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.