ArticleCell metabolism2020
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy.
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Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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143citing papers in PubMed, 1 pooled it
16.2field-weighted citation impact, top 1% of its field
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Who cites it
143 citing papers in PubMed, 1 synthesis or guideline pooled it, 199 citations in OpenAlex.
- A meta-analysis on application and prospect of cell therapy in the treatment of diabetes mellitus.Stem cell research & therapy · 2025Pooled it
- Effects of lenalidomide on the bone marrow microenvironment in acute myeloid leukemia: Translational analysis of the HOVON103 AML/SAKK30/10 Swiss trial cohort.Annals of hematology · 2021Trial
- Bone marrow stromal cells promote chemoresistance in acute myeloid leukaemia through P2RX7-mediated antioxidant defence.Experimental & molecular medicine · 2026Article
- Review
- Shared Major Metabolic Pathways and Potential Targeted Therapies in Malignancies and Systemic Lupus Erythematosus.Biomolecules · 2026Review
- Bone marrow mesenchymal stem cells are functionally remodeled after complete remission of acute myeloid leukemia.Journal of translational internal medicine · 2026Article
- A stromal-derived five-gene signature predicts gastric cancer recurrence through integrated bioinformatics and single-cell analysis.Translational cancer research · 2026Article
- Stromal and endothelial transcriptional changes during progression from MGUS to myeloma and after treatment response.Nature communications · 2026Article
- The metabolic plasticity of cancer stem cells: bidirectional crosstalk with organ-resident cells.Experimental & molecular medicine · 2026Review
- Longitudinal localization of leukaemic stem cells between the metaphysis and central marrow governs their behaviour.Nature cell biology · 2026Article
- Nestin/CXCL12 immunohistochemistry and RNA sequencing map the bone marrow microenvironment in aplastic anemia.Disease models & mechanisms · 2026Article
- Targeting dormant cancer cells: ferroptosis as a precision therapeutic strategy.Cellular & molecular biology letters · 2026Review
- Intrinsic and niche-dependent metabolic regulation of haematopoietic stem cells and implications for leukaemogenesis.Nature cell biology · 2026Review
- Marrow leptin-LEPR signaling rewires mitochondrial oxidative metabolism to confer chemoresistance in acute myeloid leukemia.Cell death & disease · 2026Article
- Review
- Single-cell profiling reveals reprogrammed hierarchy and disrupted immune-stromal ecosystem in TP53-mutated AML.Experimental hematology & oncology · 2026Article
- TRIM21 contributes to senile osteoporosis by shifting the osteoadipogenic balance toward adipogenesis in BMSCs.Science China. Life sciences · 2026Article
- Hematopoietic (stem) cells-The elixir of life?FEBS letters · 2026Review
- Acute myeloid leukemia (AML)-derived bone mesenchymal stem cell exosomal METTL14 promotes AML cell growth and glycolysis by HOXA3/WNT7B axis.Cell biology and toxicology · 2026Article
- Mitochondrial transfer in cancer: mechanisms, immune evasion, and therapeutic opportunities.Genomics & informatics · 2026Review
83 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
24 authors at 10 institutions in 4 countries.
Dorian ForteWellcome-MRC Cambridge Stem Cell Institute, CB2 0AW Cambridge, UK; National Health Service Blood and Transplant, CB2 0PT Cambridge, UK; Istituto di Ematologia "Seràgnoli", Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università degli Studi, 40138 Bologna, Italy.
María García-FernándezWellcome-MRC Cambridge Stem Cell Institute, CB2 0AW Cambridge, UK; National Health Service Blood and Transplant, CB2 0PT Cambridge, UK.
Abel Sánchez-AguileraCentro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Vaia StavropoulouUniversity Children's Hospital and Department of Biomedicine (DBM), University of Basel, 4031 Basel, Switzerland.
Claire FieldingWellcome-MRC Cambridge Stem Cell Institute, CB2 0AW Cambridge, UK; National Health Service Blood and Transplant, CB2 0PT Cambridge, UK.
Daniel Martín-PérezCentro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Juan Antonio LópezCentro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
Ana S H CostaMRC Cancer Unit, University of Cambridge, CB2 0XZ Cambridge, UK.
Laura TronciMRC Cancer Unit, University of Cambridge, CB2 0XZ Cambridge, UK.
Efterpi NikitopoulouMRC Cancer Unit, University of Cambridge, CB2 0XZ Cambridge, UK.
Michael BarberWellcome-MRC Cambridge Stem Cell Institute, CB2 0AW Cambridge, UK.
Paolo GallipoliWellcome-MRC Cambridge Stem Cell Institute, CB2 0AW Cambridge, UK; Department of Haematology, University of Cambridge, CB2 0AW Cambridge, UK.
Ludovica MarandoWellcome-MRC Cambridge Stem Cell Institute, CB2 0AW Cambridge, UK; Department of Haematology, University of Cambridge, CB2 0AW Cambridge, UK.
Carlos López Fernández de CastillejoCentro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Alexandar TzankovInstitute of Pathology, University Hospital Basel, 4031 Basel, Switzerland.
Sabine DietmannWellcome-MRC Cambridge Stem Cell Institute, CB2 0AW Cambridge, UK.
Michele CavoIstituto di Ematologia "Seràgnoli", Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università degli Studi, 40138 Bologna, Italy; Azienda Ospedaliero-Universitaria di Bologna, via Albertoni 15, 40138 Bologna, Italy.
Lucia CataniIstituto di Ematologia "Seràgnoli", Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università degli Studi, 40138 Bologna, Italy; Azienda Ospedaliero-Universitaria di Bologna, via Albertoni 15, 40138 Bologna, Italy.
Antonio CurtiAzienda Ospedaliero-Universitaria di Bologna, via Albertoni 15, 40138 Bologna, Italy.
Jesús VázquezCentro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
Christian FrezzaMRC Cancer Unit, University of Cambridge, CB2 0XZ Cambridge, UK.
Brian J HuntlyWellcome-MRC Cambridge Stem Cell Institute, CB2 0AW Cambridge, UK; Department of Haematology, University of Cambridge, CB2 0AW Cambridge, UK.
Juerg SchwallerUniversity Children's Hospital and Department of Biomedicine (DBM), University of Basel, 4031 Basel, Switzerland. Electronic address: j.schwaller@unibas.ch.
Simón Méndez-FerrerWellcome-MRC Cambridge Stem Cell Institute, CB2 0AW Cambridge, UK; Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain. Electronic address: sm2116@cam.ac.uk.
Wellcome/MRC Cambridge Stem Cell Institute · GBSpanish National Centre for Cardiovascular Research · ESAzienda USL di Bologna · ITMRC Cancer Unit · GBNational Health Service · GBUniversity of Basel · CHUniversity of Cambridge · GBCentro de Investigación en Red en Enfermedades Cardiovasculares · ESIstituto di Ematologia di Bologna · ITUniversity Hospital of Basel · CH
Funding
Cancer Research UK 25508Cancer Research UK 26670Cancer Research UK 27964Cancer Research UK C61367/A26670Howard Hughes Medical InstituteMedical Research Council MC_PC_12009Medical Research Council MC_PC_17230Medical Research Council MC_UU_12022/6Medical Research Council MR/V005421/1Wellcome TrustWellcome Trust 203151/Z/16/Z
Abstract
Like normal hematopoietic stem cells, leukemic stem cells depend on their bone marrow (BM) microenvironment for survival, but the underlying mechanisms remain largely unknown. We have studied the contribution of nestin
Indexed as
AnimalsAntineoplastic AgentsAntioxidantsBone MarrowCells, CulturedEnergy MetabolismFemaleHumansLeukemia, Myeloid, AcuteMaleMesenchymal Stem CellsMiceMice, Inbred C57BLMiddle AgedAntineoplastic AgentsAntioxidantsacute myeloid leukemiaantioxidantbone marrow mesenchymal stem cellschemotherapyglutathionehematopoietic stem cell nichemetabolic adaptationmicroenvironmentOXPHOSTCA cycle
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.