ArticleJournal of neurophysiology2020
Redundancy and multifunctionality among spinal locomotor networks.
Article in Journal of neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- The pPVTThe journal of headache and pain · 2026Article
- Spinal maps of motoneuron activity during human locomotion: neuromechanical considerations.Frontiers in physiology · 2024Review
- Precision neuromodulation: Promises and challenges of spinal stimulation for multi-modal rehabilitation.Frontiers in rehabilitation sciences · 2023Article
- Exoskeleton gait training with spinal cord neuromodulation.Frontiers in human neuroscience · 2023Review
- Article
- Motoneuronal Regulation of Central Pattern Generator and Network Function.Advances in neurobiology · 2022Article
- Optogenetic Activation of V1 Interneurons Reveals the Multimodality of Spinal Locomotor Networks in the Neonatal Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- One more time about motor (and non-motor) synergies.Experimental brain research · 2021Review
- Spontaneous Multimodal Neural Transmission Suggests That Adult Spinal Networks Maintain an Intrinsic State of Readiness to Execute Sensorimotor Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Perceptual-motor styles.Experimental brain research · 2021Review
- Why Firing Rate Distributions Are Important for Understanding Spinal Central Pattern Generators.Frontiers in human neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 3 countries.
Funding
Abstract
c-Fos is used to identify system-wide neural activation with cellular resolution in vivo. However, c-Fos can only capture neural activation of one event. Targeted recombination in active populations (TRAP) allows the capture of two different c-Fos activation patterns in the same animal. So far, TRAP has only been used to examine brain circuits. This study uses TRAP to investigate spinal circuit activation during resting and stepping, giving novel insights of network activation during these events. The level of colabeled (c-Fos+ and TRAP+) neurons observed after performing two bouts of stepping suggests that there is a probabilistic-like phenomenon that can recruit many combinations of neural populations (synapses) when repetitively generating many step cycles. Between two 30-min bouts of stepping, each consisting of thousands of steps, only ∼20% of the neurons activated from the first bout of stepping were also activated by the second bout. We also show colabeling of interneurons that have been active during stepping and resting. The use of the FosTRAP methodology in the spinal cord provides a new tool to compare the engagement of different populations of spinal interneurons in vivo under different motor tasks or under different conditions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.