ArticleAmerican journal of respiratory and critical care medicine2021
Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African Americans.
Abstract readComparative Study
In one paragraph
Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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21citing papers in PubMed, 1 pooled it
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-Wide Association Study Identifies Pharmacogenomic Variants Associated With Metformin Glycemic Response in African American Patients With Type 2 Diabetes.Diabetes care · 2024Pooled it
- Distinct blood transcriptomic profiling underlying asthma establishment and exacerbation.The journal of allergy and clinical immunology. Global · 2026Article
- Triggering mechanisms of acute thunderstorm asthma: epithelial barrier disruption and immune dysregulation.Respiratory research · 2026Review
- Gasdermin family: a promising therapeutic target for asthma.Frontiers in medicine · 2026Review
- Functional sequence variants of intergenic long noncoding RNA on chromosome 17q21 are associated with asthma.The European respiratory journal · 2025Article
- HLA variation associated with peanut allergy and anaphylaxis among non-Hispanic Black individuals.The journal of allergy and clinical immunology. Global · 2025Article
- Pyroptosis, gasdermins and allergic diseases.Allergy · 2024Review
- Advances in non-type 2 severe asthma: from molecular insights to novel treatment strategies.The European respiratory journal · 2024Review
- Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signalling and airway inflammation.The European respiratory journal · 2024Article
- The Asthma Risk Gene,Journal of respiratory biology and translational medicine · 2024Article
- Differences in Self-Reported Food Allergy and Food-Associated Anaphylaxis by Race and Ethnicity Among SAPPHIRE Cohort Participants.The journal of allergy and clinical immunology. In practice · 2023Article
- Airway wall splice quantitative trait locus analysis reveals novel downstream mechanisms for known asthma single-nucleotide polymorphisms.ERJ open research · 2023Article
- New Insights Relating Gasdermin B to the Onset of Childhood Asthma.American journal of respiratory cell and molecular biology · 2022Review
- African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans.Genome medicine · 2022Article
- "Stick a Fork in Me; I'm Done": Epithelial Cell Expression of ORMDL Sphingolipid Biosynthesis Regulator 3 Mediates Autophagic Cell Death.American journal of respiratory cell and molecular biology · 2022Article
- 17q12-q21 variants interact with early-life exposures to modify asthma risk in Black children.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Article
- An Overview of Health Disparities in Asthma.The Yale journal of biology and medicine · 2021Review
- Pyroptosis, metabolism, and tumor immune microenvironment.Clinical and translational medicine · 2021Review
- Understanding How Asthma Starts: Longitudinal Patterns of Wheeze and the Chromosome 17q Locus.American journal of respiratory and critical care medicine · 2021Article
- Diversity and the Splice of Life: Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African American Individuals.American journal of respiratory and critical care medicine · 2021Article
Corrections and comments
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Authors and funding
30 authors.
Hongsheng GuiDepartment of Internal Medicine, Center for Individualized and Genomic Medicine Research and.
Albert M LevinDepartment of Public Health Sciences, Henry Ford Health System, Detroit, Michigan.
Donglei HuDepartment of Medicine.
Patrick SleimanCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Shujie XiaoDepartment of Internal Medicine, Center for Individualized and Genomic Medicine Research and.
Angel C Y MakDepartment of Medicine.
Mao YangDepartment of Internal Medicine, Center for Individualized and Genomic Medicine Research and.
Andrea J BarczakLung Biology Center.
Scott HuntsmanDepartment of Medicine.
Celeste EngDepartment of Medicine.
Samantha HochstadtDepartment of Internal Medicine, Center for Individualized and Genomic Medicine Research and.
Ellen ZhangDepartment of Internal Medicine, Center for Individualized and Genomic Medicine Research and.
Kyle WhitehouseDepartment of Internal Medicine, Center for Individualized and Genomic Medicine Research and.
Samantha SimonsDepartment of Internal Medicine, Center for Individualized and Genomic Medicine Research and.
Whitney CabralDepartment of Internal Medicine, Center for Individualized and Genomic Medicine Research and.
Sami TakritiDepartment of Internal Medicine, Center for Individualized and Genomic Medicine Research and.
Gonçalo AbecasisCenter for Statistical Genetics, University of Michigan, Ann Arbor, Michigan.
Thomas W BlackwellCenter for Statistical Genetics, University of Michigan, Ann Arbor, Michigan.
Hyun Min KangCenter for Statistical Genetics, University of Michigan, Ann Arbor, Michigan.
Deborah A NickersonDepartment of Genome Sciences, University of Washington, Seattle, Washington.
Soren GermerNew York Genome Center, New York, New York.
David E LanfearDepartment of Internal Medicine, Center for Individualized and Genomic Medicine Research and.
Frank GillilandDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
W James GaudermanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Rajesh KumarDepartment of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; and.
David J ErleDepartment of Medicine.ORCID 0000-0002-2171-0648
Fernando D MartinezArizona Respiratory Center and.
Hakon HakonarsonCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Esteban G BurchardDepartment of Medicine.
L Keoki WilliamsDepartment of Internal Medicine, Center for Individualized and Genomic Medicine Research and.
Funding
Understanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2008 to 2026
$41.1MSOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7MStudies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5MThe Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MAirway epithelial cell gene regulation: new mechanisms and therapeutic strategiesR35HL145235 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ERLE, DAVID J · 2019 to 2025
$6.8MSocial Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIBBINS-DOMINGO, KIRSTEN · 2012 to 2016
$6.4MGene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4MTranscriptomic and Pharmacogenetic Asthma Endotypes in Minority ChildrenR01HL135156 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A, ZIV, ELAD · 2017 to 2021
$4.1MPHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMAR01AI079139 · NIAID · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2009 to 2013
$3.9MGenes, air pollution, and asthma severity in minority childrenR01MD010443 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEIBOLD, MAX A, ZIV, ELAD · 2016 to 2020
$3.8MLeveraging electronic medical records to perform large-scale diabetes pharmacogenomics among ancestrally diverse patient populationsR01DK113003 · NIDDK · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2017 to 2021
$3.2MNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS R01 HL079055NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL118267NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL128439NHLBI NIH HHS R01 HL135156NHLBI NIH HHS R01 HL141845NHLBI NIH HHS R35 HL145235NIAID NIH HHS R01 AI061774NIAID NIH HHS R01 AI079139NIAID NIH HHS U19 AI077439NIDDK NIH HHS R01 DK064695NIDDK NIH HHS R01 DK113003NIEHS NIH HHS HHSN268201600032CNIEHS NIH HHS P30 ES006694NIEHS NIH HHS R01 ES015794NIEHS NIH HHS R21 ES024844NIMHD NIH HHS P60 MD006902NIMHD NIH HHS R01 MD010443
Abstract
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Indexed as
Chromosomes, Human, Pair 17Genetic Association StudiesAdolescentAdultAge of OnsetAsthmaBlack or African AmericanChildChild, PreschoolChromosome MappingFemaleGenetic Predisposition to DiseaseGenetic VariationHumansInfantInfant, NewbornAfrican Americansasthmachromosome 17GSDMBORMDL3
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.