ArticleMolecular biology and evolution2021
A Truncated Singleton NLR Causes Hybrid Necrosis in Arabidopsis thaliana.
Article in Molecular biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 45 citations in OpenAlex.
- Graft compatibility emerges from the balance between regeneration and immunity: lessons from plant-plant interactions.Frontiers in plant science · 2026Review
- miR825-5p-regulated TNLs govern Arabidopsis resistance to Tetranychus urticae and Pieris brassicae.The New phytologist · 2025Article
- A physical model links structure and function in the plant immune system.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The resistance awakens: Diversity at the DNA, RNA, and protein levels informs engineering of plant immune receptors from Arabidopsis to crops.The Plant cell · 2025Review
- Graft incompatibility between pepper and tomato elicits an immune response and triggers localized cell death.Horticulture research · 2024Article
- Phenotypic characterization and gene mapping of hybrid necrosis in Triticum durum-Haynaldia villosa amphiploids.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- A pan-genome of 69 Arabidopsis thaliana accessions reveals a conserved genome structure throughout the global species range.Nature genetics · 2024Article
- Graft incompatibility between pepper and tomato can be attributed to genetic incompatibility between diverged immune systems.bioRxiv : the preprint server for biology · 2024Article
- Deleterious phenotypes in wild Arabidopsis arenosa populations are common and linked to runs of homozygosity.G3 (Bethesda, Md.) · 2024Article
- Genetic Cause of Hybrid Lethality Observed in Reciprocal Interspecific Crosses betweenInternational journal of molecular sciences · 2024Article
- Ectopic expression of a truncated NLR gene from wildFrontiers in plant science · 2024Article
- Mechanisms of Intrinsic Postzygotic Isolation: From Traditional Genic and Chromosomal Views to Genomic and Epigenetic Perspectives.Cold Spring Harbor perspectives in biology · 2023Review
- Genomics of plant speciation.Plant communications · 2023Review
- A recessive LRR-RLK gene causes hybrid breakdown in cotton.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Is localized acquired resistance the mechanism for effector-triggered disease resistance in plants?Nature plants · 2023Review
- Article
- Tight genetic linkage of genes causing hybrid necrosis and pollinator isolation between young species.Nature plants · 2023Article
- Pushing the limits of HiFi assemblies reveals centromere diversity between two Arabidopsis thaliana genomes.Nucleic acids research · 2022Article
- The N-terminally truncated helper NLR NRG1C antagonizes immunity mediated by its full-length neighbors NRG1A and NRG1B.The Plant cell · 2022Article
- Plant autoimmunity-fresh insights into an old phenomenon.Plant physiology · 2022Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hybrid necrosis in plants arises from conflict between divergent alleles of immunity genes contributed by different parents, resulting in autoimmunity. We investigate a severe hybrid necrosis case in Arabidopsis thaliana, where the hybrid does not develop past the cotyledon stage and dies 3 weeks after sowing. Massive transcriptional changes take place in the hybrid, including the upregulation of most NLR (nucleotide-binding site leucine-rich repeat) disease-resistance genes. This is due to an incompatible interaction between the singleton TIR-NLR gene DANGEROUS MIX 10 (DM10), which was recently relocated from a larger NLR cluster, and an unlinked locus, DANGEROUS MIX 11 (DM11). There are multiple DM10 allelic variants in the global A. thaliana population, several of which have premature stop codons. One of these, which has a truncated LRR-PL (leucine-rich repeat [LRR]-post-LRR) region, corresponds to the DM10 risk allele. The DM10 locus and the adjacent genomic region in the risk allele carriers are highly differentiated from those in the nonrisk carriers in the global A. thaliana population, suggesting that this allele became geographically widespread only relatively recently. The DM11 risk allele is much rarer and found only in two accessions from southwestern Spain-a region from which the DM10 risk haplotype is absent-indicating that the ranges of DM10 and DM11 risk alleles may be nonoverlapping.
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