Evidence map›Paper›PMID 32966160›Full record

ArticleMolecular biology of the cell2020

SLC45A2 protein stability and regulation of melanosome pH determine melanocyte pigmentation.

Linh Le, Iliana E Escobar, Tina Ho, Ariel J Lefkovith, Emily Latteri, Kirk D Haltaufderhyde, Megan K Dennis, Lynn Plowright, Elena V Sviderskaya, Dorothy C Bennett and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 109 citations in OpenAlex.

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  13. Eye pigmentation-based in-ovo chicken sexing via precision breeding.Frontiers in bioengineering and biotechnology · 2026
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Linh LeDepartment of Pathology & Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Iliana E EscobarDepartment of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912.
Tina HoDepartment of Pathology & Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Ariel J LefkovithDepartment of Pathology & Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Emily LatteriDepartment of Pathology & Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Kirk D HaltaufderhydeDepartment of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912.
Megan K DennisDepartment of Pathology & Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Lynn PlowrightMolecular & Clinical Sciences Research Institute, St George's, University of London, London SW17 0RE, UK.
Elena V SviderskayaMolecular & Clinical Sciences Research Institute, St George's, University of London, London SW17 0RE, UK.
Dorothy C BennettMolecular & Clinical Sciences Research Institute, St George's, University of London, London SW17 0RE, UK.
Elena OanceaDepartment of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912.
Michael S MarksDepartment of Pathology & Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Children's Hospital of Philadelphia · USBrown University · USSt George's, University of London · GB

Funding

TRAINING PROGRAM IN CELL AND MOLECULAR BIOLOGYT32GM007229 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 1985 to 2023
$14.0M
Melanosome BiogenesisR01AR048155 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MARKS, MICHAEL S · 2002 to 2017
$4.2M
Mechanisms regulating ion transport across the melanosomal membrane in health and diseaseR01AR071382 · NIAMS · BROWN UNIVERSITY · PI MARKS, MICHAEL S, OANCEA, ELENA · 2018 to 2022
$2.2M
BLOC-1 and BLOC-2 function in melanosome maturationF32AR062476 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI DENNIS, MEGAN KATHLEEN · 2012 to 2014
$164k
NIAMS NIH HHS F32 AR062476NIAMS NIH HHS R01 AR048155NIAMS NIH HHS R01 AR071382NIGMS NIH HHS T32 GM007229Wellcome TrustWellcome Trust 108429/Z/15/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntigens, NeoplasmCarrier ProteinsCell LineChloride ChannelsHeLa CellsHumansLysosomesMaleMelanocytesMelanosomesMembrane Transport ProteinsMicePigmentationProtein StabilitySkinAntigens, NeoplasmCarrier ProteinsChloride ChannelsMembrane Transport ProteinsOCA2 protein, humanSLC45A2 protein, human

Identifiers

PMID32966160
PMCPMC7927184
OpenAlexW3088358085

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.