Evidence map›Paper›PMID 32966119›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2020

Increased vascular α1-adrenergic receptor sensitivity in older adults with posttraumatic stress disorder.

Cortnie L Hartwig, Justin D Sprick, Jinhee Jeong, Yingtian Hu, Doree G Morison, C Michael Stein, Sachin Paranjape, Jeanie Park

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Resting sympathetic transduction in veterans with PTSD.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  3. Individuals with posttraumatic stress disorder have increased beat-to-beat blood pressure variability.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Insight into the Role of Psychological Factors in Oral Mucosa Diseases.International journal of molecular sciences · 2022
    Review
  8. Impaired sympathetic neural recruitment during exercise pressor reflex activation in women with post-traumatic stress disorder.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Cortnie L HartwigDivision of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0002-6612-0780
Justin D SprickDivision of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Jinhee JeongDivision of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0002-8748-8429
Yingtian HuDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Doree G MorisonDivision of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
C Michael SteinDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Sachin ParanjapeDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Jeanie ParkDivision of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0002-5799-9172
Emory University · USVanderbilt University Medical Center · US

Funding

IRACDA Fellowships in Research and Science Training (FIRST)K12GM000680 · NIGMS · EMORY UNIVERSITY · PI BROWN, LOU ANN S, MCCARTY, NAEL A · 2000 to 2024
$41.2M
Neurovascular Regulation During Exercise In Humans With Chronic Kidney DiseaseR01HL135183 · NHLBI · EMORY UNIVERSITY · PI Jeanie Park · 2017 to 2026
$5.4M
Nephrology Institutional Training Grant FLSA SupplementT32DK007656 · NIDDK · EMORY UNIVERSITY · PI SANDS, JEFF M, WALL, SUSAN MARIE · 1990 to 2020
$3.5M
Salt, Blood Pressure, and InflammationR01HL140145 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STEIN, CHARLES M. · 2018 to 2021
$2.3M
Sympatho-inhibition with Mindfulness in Chronic Kidney DiseaseR61AT010457 · NCCIH · EMORY UNIVERSITY · PI PARK, JEANIE · 2019 to 2020
$946k
Intramuscular Mechanisms Regulating Neurocirculatory Control in Chronic Kidney DiseaseF32HL147547 · NHLBI · EMORY UNIVERSITY · PI SPRICK, JUSTIN DANIEL · 2019 to 2021
$161k
Mechanisms of Sympathetic Overactivity in Post-traumatic Stress DisorderI01CX001065 · VA · VETERANS HEALTH ADMINISTRATION · PI PARK, JEANIE · 2015 to 2024
–
CSRD VA I01 CX001065HHS | National Institutes of Health (NIH) 5K12GM000680HHS | National Institutes of Health (NIH) R61AT10457HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) HL135183HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) HL140145HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) T32DK007656NCCIH NIH HHS R61 AT010457NHLBI NIH HHS F32 HL147547NHLBI NIH HHS R01 HL135183NHLBI NIH HHS R01 HL140145NIDDK NIH HHS T32 DK007656NIGMS NIH HHS K12 GM000680U.S. Department of Veterans Affairs (VA) I01CK001065
6 · The paper itself

Abstract

Posttraumatic stress disorder (PTSD) is an independent risk factor for the development of hypertension and cardiovascular disease. Patients with PTSD have heightened blood pressure and sympathetic nervous system reactivity; however, it is unclear if patients with PTSD have exaggerated vasoconstriction in response to sympathetic nerve activation that could also contribute to increased blood pressure reactivity. Therefore, we hypothesized that patients with PTSD have increased sensitivity of vascular α

Indexed as

VasoconstrictionAdrenergic alpha-1 Receptor AgonistsAge FactorsAgingBlood PressureCase-Control StudiesDose-Response Relationship, DrugFemaleHumansInfusions, IntravenousMaleMiddle AgedPhenylephrineReceptors, Adrenergic, alpha-1Signal TransductionStress Disorders, Post-TraumaticAdrenergic alpha-1 Receptor AgonistsPhenylephrineReceptors, Adrenergic, alpha-1dorsal hand vein techniquelinear variable differential transformerstress disorderssympathetic nervous systemvascular reactivity

Identifiers

PMID32966119
PMCPMC7792818
OpenAlexW3088843968

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.