ArticleHuman brain mapping2021
Dynamic functional network reconfiguration underlying the pathophysiology of schizophrenia and autism spectrum disorder.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 60 citations in OpenAlex.
- ΔBiological psychiatry. Cognitive neuroscience and neuroimaging · 2026Trial
- Classifying schizophrenia patients and healthy individuals: Whole brain SPECT functional connectivity using support vector machine classification.Neuroimage. Reports · 2026Article
- Cerebellar Contributions to Cerebral Connectivity in Severe Mental Illness: A Developmental Cascade and Predictive-Modeling Framework with Autistic Disorder as the Focal Case.Brain sciences · 2026Review
- Dynamic Resting-State Network Markers of Disruptive Behavior Problems in Youth.Biological psychiatry global open science · 2026Article
- Robustness of NeuroMark-Derived Functional Networks to fMRI Spatial Normalization Across the Human Lifespan.bioRxiv : the preprint server for biology · 2026Article
- Dynamic frontoparietal flexibility and cognitive dysfunction in schizophrenia: disentangling the roles of symptom burden and childhood trauma.Psychological medicine · 2026Article
- Transdiagnostic Profiles of BOLD Signal Variability in Autism and Schizophrenia Spectrum Disorders: Associations With Cognition and Functioning.Human brain mapping · 2026Article
- Brain functional network connectivity interpolation characterizes the neuropsychiatric continuum and heterogeneity.bioRxiv : the preprint server for biology · 2026Article
- Differential connectivity between core hubs underlying demanding executive functions in schizophrenia compared to autism and control adults.Frontiers in psychiatry · 2026Article
- Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders.Nature biomedical engineering · 2025Article
- Key regions aberrantly connected within cerebello-thalamo-cortical circuit and their genetic mechanism in schizophrenia: an fMRI meta-analysis and transcriptome study.Schizophrenia (Heidelberg, Germany) · 2025Review
- The role of prefrontal-hippocampal functional connectivity in schizophrenia-related cognitive dysfunction and the thalamic ventral midline involvement:Frontiers in neuroscience · 2025Review
- Dynamic fluctuations of intrinsic brain activity are associated with consistent topological patterns in puberty and are biomarkers of neural maturation.Network neuroscience (Cambridge, Mass.) · 2025Article
- Time-resolved instantaneous functional loci estimation (TRIFLE): Estimating time-varying allocation of spatially overlapping sources in functional magnetic resonance imaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Addressing Inconsistency in Functional Neuroimaging: A Replicable Data-Driven Multi-Scale Functional Atlas for Canonical Brain Networks.bioRxiv : the preprint server for biology · 2024Article
- Imaging-genomic spatial-modality attentive fusion for studying neuropsychiatric disorders.Human brain mapping · 2024Article
- Functional imaging derived ADHD biotypes based on deep clustering: a study on personalized medication therapy guidance.EClinicalMedicine · 2024Article
- Sex differences in the flexibility of dynamic network reconfiguration of autism spectrum disorder based on multilayer network.Brain imaging and behavior · 2024Article
- Searching Reproducible Brain Features using NeuroMark: Templates for Different Age Populations and Imaging Modalities.NeuroImage · 2024Article
- Explainable fuzzy clustering framework reveals divergent default mode network connectivity dynamics in schizophrenia.Frontiers in psychiatry · 2024Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The dynamics of the human brain span multiple spatial scales, from connectivity associated with a specific region/network to the global organization, each representing different brain mechanisms. Yet brain reconfigurations at different spatial scales are seldom explored and whether they are associated with the neural aspects of brain disorders is far from understood. In this study, we introduced a dynamic measure called step-wise functional network reconfiguration (sFNR) to characterize how brain configuration rewires at different spatial scales. We applied sFNR to two independent datasets, one includes 160 healthy controls (HCs) and 151 patients with schizophrenia (SZ) and the other one includes 314 HCs and 255 individuals with autism spectrum disorder (ASD). We found that both SZ and ASD have increased whole-brain sFNR and sFNR between cerebellar and subcortical/sensorimotor domains. At the ICN level, the abnormalities in SZ are mainly located in ICNs within subcortical, sensory, and cerebellar domains, while the abnormalities in ASD are more widespread across domains. Interestingly, the overlap SZ-ASD abnormality in sFNR between cerebellar and sensorimotor domains was correlated with the reasoning-problem-solving performance in SZ (r = -.1652, p = .0058) as well as the Autism Diagnostic Observation Schedule in ASD (r = .1853, p = .0077). Our findings suggest that dynamic reconfiguration deficits may represent a key intersecting point for SZ and ASD. The investigation of brain dynamics at different spatial scales can provide comprehensive insights into the functional reconfiguration, which might advance our knowledge of cognitive decline and other pathophysiology in brain disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.