Evidence map›Paper›PMID 32965639›Full record

ArticleInternational journal of hematology2021

Interferon therapy for pregnant patients with essential thrombocythemia in Japan.

Yoko Edahiro, Hajime Yasuda, Akihiko Gotoh, Soji Morishita, Toshifumi Suzuki, Jun Takeda, Jun Ando, Miyuki Tsutsui, Atsuo Itakura, Norio Komatsu

Abstract read
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In one paragraph

Article in International journal of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yoko EdahiroDepartment of Hematology, Juntendo University School of Medicine, 2-1-1 Hongou, Bunkyoku, Tokyo, 113-8421, Japan.
Hajime YasudaDepartment of Hematology, Juntendo University School of Medicine, 2-1-1 Hongou, Bunkyoku, Tokyo, 113-8421, Japan.
Akihiko GotohDepartment of Hematology, Juntendo University School of Medicine, 2-1-1 Hongou, Bunkyoku, Tokyo, 113-8421, Japan.
Soji MorishitaDepartment of Transfusion Medicine and Stem Cell Regulation, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Toshifumi SuzukiDepartment of Obstetrics and Gynecology, Juntendo University School of Medicine, Tokyo, Japan.
Jun TakedaDepartment of Obstetrics and Gynecology, Juntendo University School of Medicine, Tokyo, Japan.
Jun AndoDepartment of Hematology, Juntendo University School of Medicine, 2-1-1 Hongou, Bunkyoku, Tokyo, 113-8421, Japan.
Miyuki TsutsuiDepartment of Hematology, Juntendo University School of Medicine, 2-1-1 Hongou, Bunkyoku, Tokyo, 113-8421, Japan.
Atsuo ItakuraDepartment of Obstetrics and Gynecology, Juntendo University School of Medicine, Tokyo, Japan.
Norio KomatsuDepartment of Hematology, Juntendo University School of Medicine, 2-1-1 Hongou, Bunkyoku, Tokyo, 113-8421, Japan. komatsun@juntendo.ac.jp.ORCID http://orcid.org/0000-0003-1880-9126
Juntendo University · JPKeiai University · JPTokyo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Essential thrombocythemia (ET) mainly affects the elderly, but can also develop in women of childbearing age. The risk of miscarriage and other complications during pregnancy in ET patients are reported to be higher than that compared to the general population. Therefore, management of pregnancy in ET patients requires special considerations. Several groups recommend interferon (IFN) therapy for ET patients with high-risk pregnancies, but currently no guidelines are available in Japan. We report the outcomes of nine ET patients with ten consecutive high-risk pregnancies. All patients were successfully managed with IFN-α during their pregnancies. All patients also received aspirin and switched to unfractionated heparin around 36 weeks of gestation. As for the seven pregnancies in which IFN-α was started after detection of pregnancy, median platelet counts decreased from 910 to 573 × 10

Indexed as

AdultCalreticulinFemaleHumansInterferon-alphaJanus Kinase 2JapanMutationPlatelet CountPregnancyPregnancy Complications, HematologicReceptors, ThrombopoietinRetrospective StudiesThrombocythemia, EssentialTreatment OutcomeCalreticulinCALR protein, humanInterferon-alphaJAK2 protein, humanJanus Kinase 2MPL protein, humanReceptors, ThrombopoietinEssential thrombocythemiaInterferonMyeloproliferative neoplasmsPregnancySafety

Identifiers

PMID32965639
OpenAlexW3088038072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.