Evidence map›Paper›PMID 32965623›Full record

Trial reportInternational urology and nephrology2021

Melatonin ingestion before intradialytic exercise improves immune responses in hemodialysis patients.

Houssem Marzougui, Omar Hammouda, Imen Ben Dhia, Rami Maaloul, Ikram Agrebi, Hanen Chaker, Khaoula Kammoun, Mohamed Ben Hmida, Fatma Ayadi, Choumous Kallel and 4 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International urology and nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Houssem MarzouguiResearch Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia.
Omar HammoudaResearch Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia. hammouda.o@parisnanterre.fr.
Imen Ben DhiaHigh Institute of Sport and Physical Education, University of Sfax, Sfax, Tunisia.
Rami MaaloulResearch Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia.
Ikram AgrebiNephrology Department, Hedi Chaker University Hospital, University of Sfax, Sfax, Tunisia.
Hanen ChakerNephrology Department, Hedi Chaker University Hospital, University of Sfax, Sfax, Tunisia.
Khaoula KammounNephrology Department, Hedi Chaker University Hospital, University of Sfax, Sfax, Tunisia.
Mohamed Ben HmidaNephrology Department, Hedi Chaker University Hospital, University of Sfax, Sfax, Tunisia.
Fatma AyadiResearch Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia.
Choumous KallelLaboratory of Hematology, Habib Bourguiba University Hospital, University of Sfax, Sfax, Tunisia.
Tarak DrissInterdisciplinary Laboratory in Neurosciences, Physiology and Psychology: Physical Activity, Health and Learning (LINP2), UFR STAPS, UPL, Paris Nanterre University, 92000, Nanterre, France.
Mouna TurkiResearch Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia.
Hatem MasmoudiImmunology Department, Habib Bourguiba University Hospital, University of Sfax, Sfax, Tunisia.
Hend HachichaImmunology Department, Habib Bourguiba University Hospital, University of Sfax, Sfax, Tunisia.
University of Sfax · TNHopital Universitaire Hedi Chaker · TNHopital Universitaire Habib Bourguiba · TNInstitut Supérieur du Sport et de l’Éducation Physique de Sfax · TNUniversité Paris Nanterre · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe present study aimed to investigate the effects of melatonin (MEL) intake on systemic inflammation and immune responses during intradialytic exercise.

methodsThirteen hemodialysis (HD) patients volunteered to participate in the current randomized-crossover study. Immunological responses were monitored in four HD sessions at different conditions: [Exercise (EX) + MEL], [EX + Placebo (PLA)], [Control (CON) + MEL] and [CON + PLA]. MEL (3 mg) or PLA was ingested 1 h before starting exercise or the equivalent time in CON condition. During all sessions, peripheral blood samples were collected to assess c-reactive protein, complete blood count, and immune cells phenotypes before HD (T0), immediately after exercise (T1) and 1 h after exercise (T2) or at corresponding times in the CON condition.

resultsHD therapy induced a significant decrease in natural killer (NK) (p = 0.001, d = 0.85; p < 0.001, d = 1.19, respectively) and CD8

conclusionThis pilot study provides the first evidence that MEL intake alone or associated with intradialytic exercise displays potential immunoregulatory and anti-inflammatory effects. The combination of MEL with intradialytic exercise may be an appropriate anti-inflammatory therapy for HD patients.

Indexed as

ExerciseRenal DialysisAdultAntioxidantsCross-Over StudiesDouble-Blind MethodFemaleHumansImmunityInflammationKidney Failure, ChronicMaleMelatoninMiddle AgedPilot ProjectsAntioxidantsMelatoninImmune cellsInflammationIntradialytic exerciseMelatoninRenal failure

Identifiers

PMID32965623
OpenAlexW3088239211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.