Trial reportJournal of neural transmission (Vienna, Austria : 1996)2020
Transcranial random noise stimulation over the primary motor cortex in PD-MCI patients: a crossover, randomized, sham-controlled study.
Trial report in Journal of neural transmission (Vienna, Austria : 1996), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- The effect of transcranial random noise stimulation on the movement time and components of noise, co-variation, and tolerance in a perceptual-motor task.Scientific reports · 2025Trial
- Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines (2017-2025: An update) - endorsed by the European Society for Brain Stimulation (ESBS) and by the International Federation for Clinical Neurophysiology (IFCN).Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- The Use of Non-Invasive Brain Stimulation Techniques in Subjects with Parkinson's Disease and Mild Cognitive Impairment: A Systematic Review.Brain sciences · 2026Review
- Non-invasive brain stimulation: current and future applications in neurology.Nature reviews. Neurology · 2025Review
- Transcranial Random Noise Stimulation over the Dorsolateral Prefrontal Cortex in Patients with Parkinson's Disease and Mild Cognitive Impairment: A Pilot Study.Brain sciences · 2025Article
- Transcranial electrical stimulation (TES) in human motor Optimization: Mechanisms, safety, and emerging applications.Biochemistry and biophysics reports · 2025Review
- Comparing the effect of transcranial random noise stimulation and transcranial direct current stimulation over the motor cortex on motor performance in men vs. women: a randomized controlled crossover study.Frontiers in human neuroscience · 2025Article
- Brain Stimulation Techniques in Research and Clinical Practice: A Comprehensive Review of Applications and Therapeutic Potential in Parkinson's Disease.Brain sciences · 2024Review
- Effects of different types of high-definition transcranial electrical stimulation on visual working memory and contralateral delayed activity.Journal of neuroengineering and rehabilitation · 2024Article
- Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Review
- Random noise stimulation in the treatment of patients with neurological disorders.Neural regeneration research · 2022Review
- New Horizons on Non-invasive Brain Stimulation of the Social and Affective Cerebellum.Cerebellum (London, England) · 2022Review
- Novel Non-invasive Transcranial Electrical Stimulation for Parkinson's Disease.Frontiers in aging neuroscience · 2022Review
- Transcranial Current Stimulation as a Tool of Neuromodulation of Cognitive Functions in Parkinson's Disease.Frontiers in neuroscience · 2022Review
- Anodal Transcranial Direct Current Stimulation Could Modulate Cortical Excitability and the Central Cholinergic System in Akinetic Rigid-Type Parkinson's Disease: Pilot Study.Frontiers in neurology · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mild cognitive impairment (MCI) is a very common non-motor feature of Parkinson's disease (PD) and the non-amnestic single-domain is the most frequent subtype. Transcranial random noise stimulation (tRNS) is a non-invasive technique, which is capable of enhancing cortical excitability. As the main contributor to voluntary movement control, the primary motor cortex (M1) has been recently reported to be involved in higher cognitive functioning. The aim of this study is to evaluate the effects of tRNS applied over M1 in PD-MCI patients in cognitive and motor tasks. Ten PD-MCI patients, diagnosed according to the Movement Disorder Society, Level II criteria for MCI, underwent active (real) and placebo (sham) tRNS single sessions, at least 1 week apart. Patients underwent cognitive (Digit Span Forward and Backward, Digit Symbol, Visual Search, Letter Fluency, Stroop Test) and motor assessments (Unified Parkinson's Disease Rating Scale [UPDRS-ME], specific timed trials for bradykinesia, 10-m walk and Timed up and go tests) before and after each session. A significant improvement in motor ability (UPDRS-ME and lateralized scores, ps from 0.049 to 0.003) was observed after real versus sham tRNS. On the contrary, no significant differences were found in other motor tasks and cognitive assessment both after real and sham stimulations. These results confirm that tRNS is a safe and effective tool for improving motor functioning in PD-MCI. Future studies using a multisession tRNS applied over multitargeted brain areas (i.e., dorsolateral prefrontal cortex and M1) are required to clarify the role of tRNS regarding rehabilitative intervention in PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.