ArticleJournal of neural transmission (Vienna, Austria : 1996)2020
Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 12 citations in OpenAlex.
- Objective Assessment of Facial Expressions in Parkinson's Disease During Deep Brain Stimulation ON and OFF States: A Pilot Study.European journal of neurology · 2026Article
- Cognitive effects of adaptive deep brain stimulation in Parkinson's disease: stability without risk.European journal of medical research · 2025Article
- Revealing connectivity patterns of deep brain stimulation efficacy in Parkinson's disease.Scientific reports · 2024Article
- The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates.NPJ Parkinson's disease · 2023Article
- Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease.Human brain mapping · 2021Article
- Preoperative Electroencephalography-Based Machine Learning Predicts Cognitive Deterioration After Subthalamic Deep Brain Stimulation.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Electrophysiological biomarkers for deep brain stimulation outcomes in movement disorders: state of the art and future challenges.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
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8 authors at 2 institutions in 1 country.
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Abstract
Although deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson's disease (PD) is generally a successful therapy, adverse events and insufficient clinical effect can complicate the treatment in some patients. We studied clinical parameters and cortical oscillations related to STN-DBS to identify patients with suboptimal responses. High-density EEG was recorded during a visual oddball three-stimuli paradigm in DBS "off" and "on" conditions in 32 PD patients with STN-DBS. Pre-processed data were reconstructed into the source space and the time-frequency analysis was evaluated. We identified a subgroup of six patients with longer reaction times (RT) during the DBS "on" state than in the DBS "off" state after target stimuli. These subjects had lower motor responsiveness to DBS and decreased memory test results compared to the other subjects. Moreover, the alpha and beta power decrease (event-related desynchronizations, ERD), known as an activation correlate linked to motor and cognitive processing, was also reduced in the DBS "on" condition in these patients. A subgroup of PD patients with a suboptimal response to STN-DBS was identified. Evaluation of RT could potentially serve as a biomarker for responsiveness to STN-DBS.
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