ArticleEnvironmental health perspectives2020
Developing a Health Impact Model for Adult Lead Exposure and Cardiovascular Disease Mortality.
Article in Environmental health perspectives, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Pooled it
- Article
- Exposure to Lead and Coronary Artery Atherosclerosis: A Swedish Cross-Sectional Population-Based Study.Journal of the American Heart Association · 2025Article
- The global burden of lead exposure-related ischemic stroke: based on Bayesian age-period-cohort analysis.Frontiers in public health · 2025Article
- Interplay analysis of lead exposure with key cardiovascular gene polymorphisms on blood pressure in a cross-sectional study of occupational workers.Scientific reports · 2024Article
- Environmental Pollution and Cardiovascular Disease: Part 1 of 2: Air Pollution.JACC. Advances · 2024Review
- Burden of cardiovascular disease attributable to lead exposure in China: a comprehensive analysis of data from 1990 to 2019.American journal of translational research · 2024Article
- Associations of exposure to blood heavy metal mixtures withFrontiers in public health · 2024Article
- Global, regional, and national burdens of atrial fibrillation/flutter from 1990 to 2019: An age-period-cohort analysis using the Global Burden of Disease 2019 study.Journal of global health · 2023Article
- Pb-Induced Eryptosis May Provoke Thrombosis Prior to Hemolysis.International journal of molecular sciences · 2022Article
- Lead exposure is non-linearly associated with subclinical myocardial injury in the general population without cardiovascular disease.Frontiers in public health · 2022Article
- Global Trends in Mortality and Burden of Stroke Attributable to Lead Exposure From 1990 to 2019.Frontiers in cardiovascular medicine · 2022Article
- Blood lead level in Chinese adults with and without coronary artery disease.Journal of geriatric cardiology : JGC · 2021Article
- Plant Polyphenols: Potential Antidotes for Lead Exposure.Biological trace element research · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLead (Pb) is a highly toxic pollutant. Evidence suggests it is associated with cardiovascular disease (CVD)-related mortality.
objectivesWe present a rigorous approach for identifying concentration-response functions that relate adult Pb exposures to CVD mortality to inform a health impact model (HIM). We then use the model in a proof-of-concept example.
methodsBuilding on previously conducted government literature reviews and a
resultsOur literature search identified 15 studies for full-text review. Of those 15 studies, 4 fit our criteria for use in the HIM. Using population and CVD mortality rates for 40- to 80-y-olds in 2014, we estimated that 34,000-99,000 deaths have been avoided due to the lowering of blood Pb levels from 1999 to 2014. Based on these values we estimated that approximately 16%-46% of the decreased CVD-related death rate from 1999 to 2014 may be attributable to decreased blood Pb levels.
conclusionOur results demonstrate that decreases in Pb exposure can result in large benefits for the adult population. We have provided a HIM that can be used in a variety of applications from burden-of-disease estimates to regulatory impact assessments and have demonstrated its sensitivity to the choice of concentration-response function. https://doi.org/10.1289/EHP6552.
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