Evidence map›Paper›PMID 32964829›Full record

Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2021

The treatment of mild OSA with CPAP or mandibular advancement device and the effect on blood pressure and endothelial function after one year of treatment.

Thais Moura Guimarães, Dalva Poyares, Luciana Oliveira E Silva, Gabriela Luz, Glaury Coelho, Cibele Dal Fabbro, Sergio Tufik, Lia Bittencourt

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01461486 (Effectiveness of Continuous Positive Airway Pressure and Oral Appliances in Mild Obstructive Sleep Apnea), which is not on this map. Cited by 11 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 5 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01461486 nacompletednot on this map

Effectiveness of Continuous Positive Airway Pressure and Oral Appliances in Mild Obstructive Sleep Apnea: a Randomized, Parallel, Single Blind and Controlled Study

TypeinterventionalSponsorAssociação Fundo de Incentivo à PesquisaRan2011 to 2019Enrolled79ConditionsMild Obstructive Sleep Apnea SyndromeArmsContinuous Positive Airway Pressure (CPAP), Oral Appliance (BRD)
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 5 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Article
  8. The role of oral appliance therapy in obstructive sleep apnoea.European respiratory review : an official journal of the European Respiratory Society · 2023
    Review
  9. Review
  10. Management of Sleep Disturbances in Parkinson's Disease.Journal of Parkinson's disease · 2022
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Thais Moura GuimarãesDepartamento de Psicobiologia, Universidade Federal de Sao Paulo, São Paulo, Brasil.
Dalva PoyaresDepartamento de Psicobiologia, Universidade Federal de Sao Paulo, São Paulo, Brasil.
Luciana Oliveira E SilvaDepartamento de Psicobiologia, Universidade Federal de Sao Paulo, São Paulo, Brasil.
Gabriela LuzDepartamento de Pneumologia, Universidade Federal de Sao Paulo, São Paulo, Brasil.
Glaury CoelhoDepartamento de Psicobiologia, Universidade Federal de Sao Paulo, São Paulo, Brasil.
Cibele Dal FabbroDepartamento de Psicobiologia, Universidade Federal de Sao Paulo, São Paulo, Brasil.
Sergio TufikDepartamento de Psicobiologia, Universidade Federal de Sao Paulo, São Paulo, Brasil.
Lia BittencourtDepartamento de Psicobiologia, Universidade Federal de Sao Paulo, São Paulo, Brasil.
Universidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesTo evaluate and compare the effects of continuous positive airway pressure (CPAP), use of a mandibular advancement device (MAD), and no treatment on 24-hour ambulatory blood pressure monitoring and peripheral arterial tonometry at 6 and 12 months follow-up in individuals with mild obstructive sleep apnea (OSA), and in a subgroup who had an apnea-hypopnea index of < 5 events/h and adherence of ≥ 4 hours per night (effective-treatment subgroups).

methodsThe inclusion criteria were individuals with mild obstructive sleep apnea, any sex, age between 18 and 65 years, and a body mass index of ≤ 35 kg/m². Patients were randomized into CPAP, MAD, and no-treatment groups. The evaluations included physical examination, full polysomnography, 24-hour ambulatory blood pressure monitoring, and peripheral arterial tonometry at baseline and after 6 and 12 months. A generalized linear mixed model was used for comparisons.

resultsThe CPAP and MAD groups had lower apnea-hypopnea indexes than the control group at 6 and 12 months, and the CPAP group had higher blood oxygen levels (SpO₂) than the MAD group. The MAD group had more hours of treatment per night and better adaptation to treatment than the CPAP group (MAD: 5.7 ± 2.7 h/night; CPAP: 3.8 ± 3.4 h/night; MAD: 16% did not adapt; CPAP: 42% did not adapt). No differences were found in the total sample and effective treatment in relation to peripheral arterial tonometry or 24-hour ambulatory blood pressure monitoring outcomes.

conclusionsTreatment of mild obstructive sleep apnea with CPAP or MAD did not improve blood pressure or endothelial function after 1 year, even in patients with effective treatment. CLINICAL

trial registrationRegistry: ClinicalTrials.gov; Name: Continuous Positive Airway Pressure and Oral Appliances Treatments in Mild Obstructive Sleep Apnea; URL: https://clinicaltrials.gov/ct2/show/NCT01461486; Identifier: NCT01461486.

Indexed as

Mandibular AdvancementSleep Apnea, ObstructiveAdolescentAdultAgedBlood PressureBlood Pressure Monitoring, AmbulatoryContinuous Positive Airway PressureHumansMiddle AgedOcclusal SplintsTreatment OutcomeYoung AdultCPAPmandibular advancement deviceobstructive sleep apnea

Identifiers

PMID32964829
PMCPMC7853217
OpenAlexW3087788273

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.