Evidence map›Paper›PMID 32964792›Full record

SynthesisAmerican journal of men's health

Polymorphism in the Androgen Biosynthesis Gene (CYP17), a Risk for Prostate Cancer: A Meta-Analysis.

Clement Yaw Effah, Ling Wang, Clement Agboyibor, Emmanuel Kwateng Drokow, Songcheng Yu, Wei Wang, Yongjun Wu

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in American journal of men's health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. A Review onGenes · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Clement Yaw EffahCollege of Public Health, Zhengzhou University, Zhengzhou, China.ORCID 0000-0002-9095-4558
Ling WangCollege of Public Health, Zhengzhou University, Zhengzhou, China.
Clement AgboyiborSchool of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Emmanuel Kwateng DrokowDepartment of Radiation Oncology, Zhengzhou University People's Hospital & Henan Provincial People's Hospital Henan, China.
Songcheng YuCollege of Public Health, Zhengzhou University, Zhengzhou, China.
Wei WangCollege of Public Health, Zhengzhou University, Zhengzhou, China.
Yongjun WuCollege of Public Health, Zhengzhou University, Zhengzhou, China.
Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene polymorphism is one of the few factors that increases the risk of prostate cancer. T to C substitution in the 5' promoter region of the CYP17 gene is hypothesized to increase the rate of gene transcription, increase androgen production, and thereby increase the risk of prostate cancer. Nevertheless, the inconsistencies originating from studies on CYP17 polymorphism and prostate cancer prompted this meta-analysis, to decipher the association between CYP17 polymorphism and prostate cancer. Most case-control studies addressing CYP17 polymorphism and prostate cancer were exhaustively searched from Web of Science, Google Scholar, and PubMed. The various genotype distributions as well as the minor allele distributions were retrieved. Pooled odds ratios (

Indexed as

Polymorphism, GeneticAndrogensGenotypeHumansMaleProstatic NeoplasmsRisk AssessmentSteroid 17-alpha-HydroxylaseAndrogensSteroid 17-alpha-HydroxylaseandrogenCYP17polymorphismprostate cancerrisk

Identifiers

PMID32964792
PMCPMC7518003
OpenAlexW3088522632

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.