Evidence map›Paper›PMID 32964731›Full record

ArticleGlobal spine journal2022

Immune and Metabolic Biomarkers in a Rodent Model of Spinal Cord Contusion.

Christiano Dos Santos E Santos, Bradley A Welch, Shelley R Edwards, Kwamie K Harris, Brittany C Duncan, Alexandra R Himel, Bernadette E Grayson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Global spine journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christiano Dos Santos E SantosUniversity of Mississippi Medical Center, Jackson, MS, USA.
Bradley A WelchUniversity of Mississippi Medical Center, Jackson, MS, USA.
Shelley R EdwardsUniversity of Mississippi Medical Center, Jackson, MS, USA.
Kwamie K HarrisUniversity of Mississippi Medical Center, Jackson, MS, USA.
Brittany C DuncanUniversity of Mississippi Medical Center, Jackson, MS, USA.
Alexandra R HimelUniversity of Mississippi Medical Center, Jackson, MS, USA.
Bernadette E GraysonUniversity of Mississippi Medical Center, Jackson, MS, USA.ORCID https://orcid.org/0000-0002-1281-1682
Jackson Memorial Hospital · US

Funding

The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
NIGMS NIH HHS P20 GM104357
6 · The paper itself

Abstract

STUDY

designBasic science animal research study.

objectivesUsing T10 spinal contused rats, we sought to identify molecular and circulating, metabolic and immune biomarkers during the subchronic and chronic recovery periods that may inform us concerning neurorehabilitation.

methodsGene expression of the cord and ELISA were performed in 28 and 100 days in T10 injured rats and compared to sham-injured rats. Hundred-day injured rats were placed on either a low-fat or high-fat diet following the recovery phase. Linear regression analysis was performed between markers and locomotor score, body weight, body composition, and blood cholesterol and triglycerides.

resultsGene expression in the thoracic cord for complement marker, C1QC, dendritic cell marker, ITGAX, and cholesterol biosynthesis genes, FDFT1, HMCGR, LDLR, and SREBP1, were significantly associated with BBB score, body weight, composition, and other metabolic parameters. Circulating levels of these proteins, however, did not vary by injury or predict the level of locomotor recovery.

conclusionsIdentification of reliable circulating biomarkers that are durable and based on level of spinal injury are complicated by immune and metabolic comorbidities. Continued work is necessary to identify stable markers of disease progression.

Indexed as

biomarkerlocomotor activitymetabolismobesityspinal cord injury

Identifiers

PMID32964731
PMCPMC8965303
OpenAlexW3087798246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.