Evidence map›Paper›PMID 32964656›Full record

ArticleChembiochem : a European journal of chemical biology2021

Synthetic Antibody Mimics Based on Cancer-Targeting Immunostimulatory Peptides.

Dante Descalzi-Montoya, Rachel A Montel, Keith Smith, Eugenia Dziopa, Andrieh Darwich, Zheng Yang, Constantine Bitsaktsis, Robert Korngold, David Sabatino

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dante Descalzi-MontoyaCenter for Discovery and Innovation, Hackensack-Meridian Health, 340 Kingsland Street, Nutley, NJ 07110, USA.
Rachel A MontelDepartment of Biological Sciences and Chemistry and Biochemistry, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA.
Keith SmithDepartment of Biological Sciences and Chemistry and Biochemistry, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA.
Eugenia DziopaCenter for Discovery and Innovation, Hackensack-Meridian Health, 340 Kingsland Street, Nutley, NJ 07110, USA.
Andrieh DarwichDepartment of Biological Sciences and Chemistry and Biochemistry, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA.
Zheng YangCenter for Discovery and Innovation, Hackensack-Meridian Health, 340 Kingsland Street, Nutley, NJ 07110, USA.
Constantine BitsaktsisDepartment of Biological Sciences and Chemistry and Biochemistry, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA.
Robert KorngoldCenter for Discovery and Innovation, Hackensack-Meridian Health, 340 Kingsland Street, Nutley, NJ 07110, USA.
David SabatinoDepartment of Biological Sciences and Chemistry and Biochemistry, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA.ORCID 0000-0002-9797-0833
Seton Hall University · USHackensack Meridian Health · US

Funding

NK Cell-Dependent Cancer Immunotherapy with Semi-Synthetic Peptide-Protein Bio-ConjugatesR03CA216136 · NCI · SETON HALL UNIVERSITY · PI SABATINO, DAVID · 2017 to 2018
$153k
NCI NIH HHS R03 CA216136
6 · The paper itself

Abstract

De novo cancer-targeting immunostimulatory peptides have been designed and developed as synthetic antibody mimics. A series of bifunctional peptides incorporating NKp30-binding and NK-cell-activating domains were synthesized as linear dimers and then extended into branching trimeric peptides by the incorporation of GRP78-targeting and tumor-cell-binding sequences. A selected trimeric peptide from this small set of peptides displayed binding capabilities on GRP78

Indexed as

Adjuvants, ImmunologicAnimalsAntibodiesCell Line, TumorCytokinesEndoplasmic Reticulum Chaperone BiPFemaleHumansImmunotherapyKiller Cells, NaturalLymphocyte ActivationMaleMiceMice, Inbred NODMice, SCIDNeoplasmsAdjuvants, ImmunologicAntibodiesCytokinesEndoplasmic Reticulum Chaperone BiPPeptidescancer immunotherapycancer-targeting peptidesimmunostimulatory peptidespeptide vaccinessynthetic antibody mimics

Identifiers

PMID32964656
PMCPMC8191480
OpenAlexW3088311946

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.