Evidence map›Paper›PMID 32964641›Full record

ArticleJournal of biomedical materials research. Part B, Applied biomaterials2021

Antimicrobial potential of resin matrices loaded with coffee compounds.

Sarah A de Almeida, Jack L Ferracane, Eduardo M da Silva, Amanda M Mushashe, Justin Merritt, Anderson A Rocha, Jaime D Noronha-Filho, Rayane V de Almeida, Laiza T Poskus

Abstract read
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In one paragraph

Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sarah A de AlmeidaLabiom-R (Analytical Laboratory of Restorative Biomaterials), Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil.
Jack L FerracaneDepartment of Restorative Dentistry, Division of Biomaterials and Biomechanics, Oregon Health and Science University, Portland, Oregon, USA.
Eduardo M da SilvaLabiom-R (Analytical Laboratory of Restorative Biomaterials), Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil.
Amanda M MushasheSchool of Health Sciences, Universidade Positivo, Curitiba, Puerto Rico, Brazil.
Justin MerrittDepartment of Restorative Dentistry, Division of Biomaterials and Biomechanics, Oregon Health and Science University, Portland, Oregon, USA.
Anderson A RochaDepartment of Chemistry, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil.
Jaime D Noronha-FilhoLabiom-R (Analytical Laboratory of Restorative Biomaterials), Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil.
Rayane V de AlmeidaLabiom-R (Analytical Laboratory of Restorative Biomaterials), Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil.
Laiza T PoskusLabiom-R (Analytical Laboratory of Restorative Biomaterials), Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil.ORCID 0000-0002-1639-4695

Funding

Advancing studies of polymicrobial diseases via streptococcal geneticsR35DE028252 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI MERRITT, JUSTIN · 2018 to 2025
$7.8M
NIDCR NIH HHS R35 DE028252
6 · The paper itself

Abstract

This study evaluated the biological behavior of the coffee compounds Trigonelline (T), chlorogenic acid (C), and nicotinic acid (N), correlating with their release from a resin matrix. Minimum inhibitory concentration (MIC) was evaluated against Streptococcus mutans UA159, and cytotoxicity was assessed by methyl tetrazolium salt on OD-21 cells. Resin matrices (bisphenol A-glycidyl-dimethacrylate/triethylene glycol-dimethacrylate 70/30 wt%, camphorquinone/ethyl 4-dimethyl aminobenzoate 0.5/1 wt%) were doped with coffee compounds in different concentrations (10/20/30/40/50 wt%), performing 15 groups (T10-T50, C10-C50, N10-N50), and a control group with no coffee compound. Degree of conversion (DC%) was analyzed by Fourier transform infrared spectroscopy. Antimicrobial properties were evaluated by bioluminescence (Luciferase assay). The release from loaded matrices was analyzed over time (24 hr, 6, 14, 21 and 28 days), using high-performance liquid chromatography (HPLC). Data were submitted to ANOVA/Tukey's test (α = 0.05). MIC for T and C was 6 mg/ml, and 4 mg/ml for N. None of them were cytotoxic. Only T50 and C50 showed lower DC% than control (α < 0.05). Some groups (T30/T40/T50/C40/C50/N50) were strongly antimicrobial, reducing bacterial activity approximately five times compared to control (α < 0.05). For T30, T40, T50, C40, and C50, the HPLC showed a release above or closer to MIC values mainly in 24 hr, but for N50, up to 28 days. In conclusion, the coffee compounds presented antimicrobial activity, depending on their concentration when added in resin matrices, being found a correlation with their release.

Indexed as

AlkaloidsAnti-Infective AgentsChlorogenic AcidNiacinCoffeeComposite ResinsStreptococcus mutansAlkaloidsAnti-Infective AgentsChlorogenic AcidCoffeeComposite ResinsNiacintrigonellineantimicrobial potentialcoffee compoundscompounds's releasecytotoxicityresin matrix

Identifiers

PMID32964641
PMCPMC8244821

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.