Evidence map›Paper›PMID 32964529›Full record

ArticleJournal of the European Academy of Dermatology and Venereology : JEADV2021

European dermatology forum: Updated guidelines on the use of extracorporeal photopheresis 2020 - Part 2.

R Knobler, P Arenberger, A Arun, C Assaf, M Bagot, G Berlin, A Bohbot, P Calzavara-Pinton, F Child, A Cho and 18 more

Abstract read
In one paragraph

Article in Journal of the European Academy of Dermatology and Venereology : JEADV, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Review
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Extracorporeal photopheresis induces the release of anti-inflammatory fatty acids and oxylipins and suppresses pro-inflammatory sphingosine-1-phosphate.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Current Usage of Extracorporeal Photopheresis in Solid Organ Transplantations in Europe: A Narrative Review.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
  12. Article
  13. Article
  14. Extracorporeal Photopheresis in Dermatological Diseases.International journal of molecular sciences · 2024
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

R KnoblerDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-7380-7062
P ArenbergerThird Faculty of Medicine, Charles University, Prague, Czech Republic.
A ArunFRCPath, The Rotherham NHA Foundation Trust, Rotherham, United Kingdom.
C AssafDepartment of Dermatology and Venerology, Helios Klinikum Krefeld, Krefeld, Germany.
M BagotHospital Saint Louis, Université de Paris, Paris, France.
G BerlinDepartment of Clinical Immunology and Transfusion Medicine, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
A BohbotOnco-Hematology Department, Hautepierre Hospital, Strasbourg, France.
P Calzavara-PintonDermatology Department, University of Brescia Italy, Brescia, Italy.
F ChildFRCP, St John's Institution of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
A ChoDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
L E FrenchDepartment of Dermatology, University Hospital, München, Germany.
A R GenneryTranslational and Clinical Research Institute Newcastle University Great North Children's Hospital Newcastle upon Tyne, Newcastle University, Newcastle upon Tyne, United Kingdom.
R GniadeckiDivision of Dermatology, University of Alberta, Edmonton, Canada.
H P M GollnickDepartment Dermatology & Venereology Otto-von-Guericke University, Magdeburg, Germany.ORCID https://orcid.org/0000-0003-1178-1765
E GuenovaFaculty of Biology and Medicine, University of Lausanne and Department of Dermatology, Lausanne University Hospital CHUV, Lausanne, Switzerland.
P JakschDepartment of Thoracic Surgery, Medical University Vienna, Vienna, Austria.
C JantschitschDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
C KlemkeHautklinik Städtisches Klinikum Karlsruhe, Karlsruhe, Germany.
J LudvigssonCrown Princess Victoria Children's Hospital and Division of Pediatrics, Department of Biomedical and Clinical Sciences, University Hospital, Linköping University, Linköping, Sweden.
E PapadavidNational and Kapodistrian University of Athens, Athens, Greece.
J ScarisbrickUniversity Hospital Birmingham, Birmingham, United Kingdom.
T SchwarzDepartment of Dermatology, University Clinics Schleswig-Holstein, Kiel, Germany.
R StadlerUniversity Clinic for Dermatology Johannes Wesling Medical Centre, UKRUB, University of Bochum, Minden, Germany.
P WolfDepartment of Dermatology, Medical University of Graz, Graz, Austria.
J ZicVanderbilt University Medical Center Department of Dermatology, Nashville, Tennessee, USA.
C ZouboulisDepartments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane, Dessau, Germany.
A ZuckermannDepartment of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
H GreinixLKH-Univ. Klinikum Graz, Division of Haematology, Medical University of Graz, Graz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFollowing the first investigational study on the use of extracorporeal photopheresis for the treatment of cutaneous T-cell lymphoma published in 1983, this technology has received continued use and further recognition for additional earlier as well as refractory forms. After the publication of the first guidelines for this technology in the JEADV in 2014, this technology has maintained additional promise in the treatment of other severe and refractory conditions in a multidisciplinary setting. It has confirmed recognition in well-known documented conditions such as graft-vs.-host disease after allogeneic bone marrow transplantation, systemic sclerosis, solid organ transplant rejection including lung, heart and liver and to a lesser extent inflammatory bowel disease. MATERIALS AND

methodsIn order to further provide recognized expert practical guidelines for the use of this technology for all indications, the European Dermatology Forum (EDF) again proceeded to address these questions in the hands of the recognized experts within and outside the field of dermatology. This was done using the recognized and approved guidelines of EDF for this task. All authors had the opportunity to review each contribution as it was added. RESULTS AND

conclusionThese updated 2020 guidelines provide at present the most comprehensive available expert recommendations for the use of extracorporeal photopheresis based on the available published literature and expert consensus opinion. The guidelines were divided into two parts: PART I covers Cutaneous T-cell lymphoma, chronic graft-vs.-host disease and acute graft-vs.-host disease, while PART II will cover scleroderma, solid organ transplantation, Crohn's disease, use of ECP in paediatric patients, atopic dermatitis, type 1 diabetes, pemphigus, epidermolysis bullosa acquisita and erosive oral lichen planus.

Indexed as

DermatologyGraft vs Host DiseaseLymphoma, T-Cell, CutaneousPhotopheresisSkin NeoplasmsChildHumans

Identifiers

PMID32964529
PMCPMC7821314

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.