Evidence map›Paper›PMID 32964510›Full record

Observational studyHepatology (Baltimore, Md.)2020

Liver Injury in Liver Transplant Recipients With Coronavirus Disease 2019 (COVID-19): U.S. Multicenter Experience.

Atoosa Rabiee, Brett Sadowski, Nia Adeniji, Ponni V Perumalswami, Veronica Nguyen, Akshata Moghe, Nyan L Latt, Sonal Kumar, Costica Aloman, Andreea M Catana and 9 more

Registry-linked trialOpen access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Hepatology (Baltimore, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04439084 (COVID-19 in Patients With Chronic Liver Diseases), which is not on this map. Cited by 50 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04439084 completednot on this map

COVID-19 in Patients With Chronic Liver Diseases

TypeobservationalSponsorStanford UniversityRan2020 to 2021Enrolled1,025ConditionsCOVID-19, Chronic Liver DiseaseArmsProspective Chart Review
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. COVID-19 and solid organ transplantation: Finding the right balance.Transplantation reviews (Orlando, Fla.) · 2022
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
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  15. Review
  16. Review
  17. COVID-19 vaccination and liver disease.World journal of gastroenterology · 2022
    Review
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  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 15 institutions in 1 country.

Atoosa Rabiee *Division of Gastroenterology, VA Medical Center, Washington, DC.
Brett Sadowski *Division of Gastroenterology, Georgetown University, Washington, DC.
Nia AdenijiDivision of Gastroenterology, Stanford University, Stanford, CA.ORCID 0000-0002-7957-5987
Ponni V PerumalswamiDivision of Gastroenterology, Icahn School of Medicine at Mount Sinai, NY.
Veronica NguyenDivision of Gastroenterology, University of Arizona, AZ.
Akshata MogheDivision of Gastroenterology, University of Pittsburgh Medical Center, PA.
Nyan L LattDivision of Gastroenterology, Ochsner Medical Center, LA.
Sonal KumarDivision of Gastroenterology, Weill Cornell Medicine, NY.
Costica AlomanDivision of Gastroenterology, Rush University Medical Center, IL.
Andreea M CatanaDivision of Gastroenterology, Beth Israel Deaconess Medical Center, MA.
Patricia P BloomMassachusetts General Hospital, MA.ORCID 0000-0003-3188-7188
Kenneth D ChavinDivision of Transplant and Hepatobiliary Surgery, University Hospitals Cleveland Medical Center, OH.
Rotonya M CarrDivision of Gastroenterology, University of Pennsylvania, PA.
Winston DunnDivision of Gastroenterology, Kansas University Medical Center, KS.
Vincent L ChenDivision of Gastroenterology, University of Michigan, MI.
Elizabeth S AbyDivision of Gastroenterology, University of Minnesota, MN.
Jose D DebesDivision of Gastroenterology, University of Minnesota, MN.
Renumathy DhanasekaranDivision of Gastroenterology, Stanford University, Stanford, CA.ORCID 0000-0001-8819-7511
COLD Consortium *
Georgetown University · USStanford University · USUniversity of Minnesota · USBeth Israel Deaconess Medical Center · USCornell University · USIcahn School of Medicine at Mount Sinai · USMassachusetts General Hospital · USOchsner Medical Center · USRush University Medical Center · USUniversity Medical Center · USUniversity of Arizona · USUniversity of Michigan · USUniversity of Pennsylvania · USUniversity of Pittsburgh Medical Center · USWashington DC VA Medical Center · US

Funding

Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
Training in Basic and Translational Digestive SciencesT32DK094775 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN Y KAO, LINDA C. SAMUELSON · 2012 to 2026
$3.6M
Targeting mononuclear phagocytes development in alcohol induced liver damage: pathological and immunological pathwaysR01AA024762 · NIAAA · RUSH UNIVERSITY MEDICAL CENTER · PI ALOMAN, COSTICA · 2017 to 2021
$1.7M
Factors Responsible for Liver Recovery After Successful Treatment of Hepatitis C.K23DK109294 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI DUNN, WINSTON · 2017 to 2021
$1.0M
NCATS NIH HHS UL1 TR002384NIAAA NIH HHS R01 AA024762NIDDK NIH HHS K23 DK109294NIDDK NIH HHS T32 DK094775
6 · The paper itself

Abstract

BACKGROUND AND

aimsCoronavirus disease 2019 (COVID-19) is associated with liver injury, but the prevalence and patterns of liver injury in liver transplantation (LT) recipients with COVID-19 are open for study. APPROACH AND

resultsWe conducted a multicenter study in the United States of 112 adult LT recipients with COVID-19. Median age was 61 years (interquartile range, 20), 54.5% (n = 61) were male, and 39.3% (n = 44) Hispanic. Mortality rate was 22.3% (n = 25); 72.3% (n = 81) were hospitalized and 26.8% (n = 30) admitted to the intensive care unit (ICU). Analysis of peak values of alanine aminotransferase (ALT) during COVID-19 showed moderate liver injury (ALT 2-5× upper limit of normal [ULN]) in 22.2% (n = 18) and severe liver injury (ALT > 5× ULN) in 12.3% (n = 10). Compared to age- and sex-matched nontransplant patients with chronic liver disease and COVID-19 (n = 375), incidence of acute liver injury was lower in LT recipients (47.5% vs. 34.6%; P = 0.037). Variables associated with liver injury in LT recipients were younger age (P = 0.009; odds ratio [OR], 2.06; 95% confidence interval [CI], 1.20-3.54), Hispanic ethnicity (P = 0.011; OR, 6.01; 95% CI, 1.51-23.9), metabolic syndrome (P = 0.016; OR, 5.87; 95% CI, 1.38-24.99), vasopressor use (P = 0.018; OR, 7.34; 95% CI, 1.39-38.52), and antibiotic use (P = 0.046; OR, 6.93; 95% CI, 1.04-46.26). Reduction in immunosuppression (49.4%) was not associated with liver injury (P = 0.156) or mortality (P = 0.084). Liver injury during COVID-19 was significantly associated with mortality (P = 0.007; OR, 6.91; 95% CI, 1.68-28.48) and ICU admission (P = 0.007; OR, 7.93; 95% CI, 1.75-35.69) in LT recipients.

conclusionsLiver injury is associated with higher mortality and ICU admission in LT recipients with COVID-19. Hence, monitoring liver enzymes closely can help in early identification of patients at risk for adverse outcomes. Reduction of immunosuppression during COVID-19 did not increase risk for mortality or graft failure.

Indexed as

SARS-CoV-2Acute Lung InjuryAdultAgedAged, 80 and overAlanine TransaminaseCohort StudiesCOVID-19FemaleHumansImmunosuppression TherapyLiver TransplantationLogistic ModelsMaleMiddle AgedAlanine Transaminase

Identifiers

PMID32964510
PMCPMC7537191
OpenAlexW3087358376

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.