Evidence map›Paper›PMID 32964493›Full record

ArticleGenetic epidemiology2021

Loci identified by a genome-wide association study of carotid artery stenosis in the eMERGE network.

Melody R Palmer, Daniel S Kim, David R Crosslin, Ian B Stanaway, Elisabeth A Rosenthal, David S Carrell, David J Cronkite, Adam Gordon, Xiaomeng Du, Yatong K Li and 15 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetic epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 10 institutions in 1 country.

Melody R PalmerDivision of Medical Genetics, School of Medicine, University of Washington, Seattle, Washington, USA.
Daniel S KimDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
David R CrosslinDepartment of Biomedical Informatics and Medical Education, School of Medicine, University of Washington, Seattle, Washington, USA.
Ian B StanawayDepartment of Biomedical Informatics and Medical Education, School of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-0783-0918
Elisabeth A RosenthalDivision of Medical Genetics, School of Medicine, University of Washington, Seattle, Washington, USA.
David S CarrellKaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
David J CronkiteKaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
Adam GordonCenter for Genetic Medicine, Northwestern University, Chicago, Illinois, USA.
Xiaomeng DuDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Yatong K LiDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Marc S WilliamsGenomic Medicine Institute, Geisinger, Danville, Pennsylvania, USA.
Chunhua WengDepartment of Biomedical Informatics, Columbia University, New York, New York, USA.
Qiping FengDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Rongling LiDivision of Genomic Medicine, National Human Genome Research Institute, Bethesda, Maryland, USA.
Sarah A PendergrassGeisinger Research, Rockville, Maryland, USA.
Hakon HakonarsonDepartment of Pediatrics, The Center for Applied Genomics, Children's Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
David FaselDepartment of Biomedical Informatics, Columbia University, New York, New York, USA.
Sunghwan SohnMayo Clinic, Rochester, Minnesota, USA.
Patrick SleimanDepartment of Pediatrics, The Children's Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Samuel K HandelmanDivision of Gastroenterology, Department of Internal Medicine and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
Elizabeth SpeliotesDivision of Gastroenterology, Department of Internal Medicine and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
Iftikhar J KulloDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Eric B LarsonKaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
eMERGE ConsortiumThe electronic Medical Records and GEnomics Network, NHGRI, NIH, Bethesda, Maryland, USA.
Gail P JarvikDivision of Medical Genetics, School of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-6710-8708
University of Michigan · USUniversity of Washington Medical Center · USKaiser Permanente Washington Health Research Institute · USChildren's Hospital of Philadelphia · USColumbia University · USMayo Clinic · USGeisinger Neuroscience Institute · USNational Human Genome Research Institute · USNorthwestern University · USVanderbilt University Medical Center · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
JH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2M
A Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4M
Genomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5M
University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
Finding Genomic Profiles of COVID-19 Phenotypes from the EHRU01HG008685 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIZABETH W KARLSON, Matthew S Lebo · 2015 to 2026
$13.6M
Variation, Function, and Disease Supplement ProgramU01HG008657 · NHGRI · UNIVERSITY OF WASHINGTON · PI David Russell Crosslin, Gail Pairitz Jarvik · 2015 to 2026
$13.4M
OMOP information model for eMERGE phenotypingU01HG008680 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wendy K Chung, GEORGE M HRIPCSAK · 2015 to 2026
$13.3M
DNA Sequencing Support for the eMERGE NetworkU01HG008664 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2015 to 2019
$10.9M
Global Alliance for Genomic Health (GA4GH)U01HG008676 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI LENNON, NIALL JOHN, REHM, HEIDI L · 2015 to 2019
$8.6M
The Electronic Medical Records and Genomics (eMERGE) Network Phase III Coordinating Center (U01)U01HG008701 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PETERSON, JOSEPH F. · 2015 to 2019
$7.1M
eMERGE Coordinating Center - Administrative SupplementU01HG006385 · NHGRI · VANDERBILT UNIVERSITY · PI HARRIS, PAUL A. · 2011 to 2014
$5.4M
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NCATS NIH HHS UL1 TR002373NHGRI NIH HHS T32 HG000040NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG006375NHGRI NIH HHS U01 HG006378NHGRI NIH HHS U01 HG006379NHGRI NIH HHS U01 HG006380NHGRI NIH HHS U01 HG006382NHGRI NIH HHS U01 HG006385NHGRI NIH HHS U01 HG006388NHGRI NIH HHS U01 HG006389NHGRI NIH HHS U01 HG006828NHGRI NIH HHS U01 HG006830NHGRI NIH HHS U01 HG008657NHGRI NIH HHS U01 HG008664NHGRI NIH HHS U01 HG008666NHGRI NIH HHS U01 HG008672NHGRI NIH HHS U01 HG008673NHGRI NIH HHS U01 HG008676NHGRI NIH HHS U01 HG008679NHGRI NIH HHS U01 HG008680NHGRI NIH HHS U01 HG008684NHGRI NIH HHS U01 HG008685NHGRI NIH HHS U01 HG008701
6 · The paper itself

Abstract

Carotid artery atherosclerotic disease (CAAD) is a risk factor for stroke. We used a genome-wide association (GWAS) approach to discover genetic variants associated with CAAD in participants in the electronic Medical Records and Genomics (eMERGE) Network. We identified adult CAAD cases with unilateral or bilateral carotid artery stenosis and controls without evidence of stenosis from electronic health records at eight eMERGE sites. We performed GWAS with a model adjusting for age, sex, study site, and genetic principal components of ancestry. In eMERGE we found 1793 CAAD cases and 17,958 controls. Two loci reached genome-wide significance, on chr6 in LPA (rs10455872, odds ratio [OR] (95% confidence interval [CI]) = 1.50 (1.30-1.73), p = 2.1 × 10

Indexed as

Carotid StenosisGenome-Wide Association StudyElectronic Health RecordsGenetic Predisposition to DiseaseGenomicsHumansLipoprotein(a)Models, GeneticPolymorphism, Single NucleotideLipoprotein(a)carotid artery atherosclerosiselectronic health recordsgenome-wide association study

Identifiers

PMID32964493
PMCPMC7891640
OpenAlexW3089324636

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.