ArticleHepatology (Baltimore, Md.)2021
The Apelin-Apelin Receptor Axis Triggers Cholangiocyte Proliferation and Liver Fibrosis During Mouse Models of Cholestasis.
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Article in Hepatology (Baltimore, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 43 citations in OpenAlex.
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- Identification of AKR1B10 as a key gene in primary biliary cholangitis by integrated bioinformatics analysis and experimental validation.Frontiers in molecular biosciences · 2023Article
- Apelin-13 Protects Neurons by Attenuating Early-Stage Postspinal Cord Injury Apoptosis In Vitro.Brain sciences · 2022Article
- Predictive and Diagnostic Value of Serum Adipokines in Pregnant Women with Intrahepatic Cholestasis.International journal of environmental research and public health · 2022Article
- Recent discoveries in microbiota dysbiosis, cholangiocytic factors, and models for studying the pathogenesis of primary sclerosing cholangitis.Open medicine (Warsaw, Poland) · 2022Review
- NOX4: a potential therapeutic target for pancreatic cancer and its mechanism.Journal of translational medicine · 2021Review
- METTL3/N6-methyladenosine/ miR-21-5p promotes obstructive renal fibrosis by regulating inflammation through SPRY1/ERK/NF-κB pathway activation.Journal of cellular and molecular medicine · 2021Article
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Authors and funding
15 authors at 6 institutions in 2 countries.
Lixian ChenDepartment of Medical Physiology, Texas A&M University College of Medicine, Bryan, TX.
Tianhao ZhouDepartment of Medical Physiology, Texas A&M University College of Medicine, Bryan, TX.
Tori WhiteDepartment of Medical Physiology, Texas A&M University College of Medicine, Bryan, TX.
April O'BrienDepartment of Medical Physiology, Texas A&M University College of Medicine, Bryan, TX.
Sanjukta ChakrabortyDepartment of Medical Physiology, Texas A&M University College of Medicine, Bryan, TX.
Suthat LiangpunsakulDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Zhihong YangDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Lindsey KennedyDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Romil SaxenaDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.
Chaodong WuDepartment of Nutrition, Texas A&M University, College Station, TX.
Fanyin MengDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Qiaobing HuangDepartment of Pathophysiology, Guangdong Provincial Key Lab of Shock and Microcirculation, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P. R. China.
Heather FrancisDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Gianfranco AlpiniDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Shannon GlaserDepartment of Medical Physiology, Texas A&M University College of Medicine, Bryan, TX.
Indiana University School of MedicineTexas A&M University · USIndiana University – Purdue University Indianapolis · USBryan College · USRichard L. Roudebush VA Medical Center · USSouthern Medical University · CN
Funding
GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREER01DK054811 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2000 to 2021
$3.8MThe Paracrine Regulation of Mast Cells During Biliary/Cholangiocyte Repair and DamageR01DK108959 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI FRANCIS, HEATHER L · 2016 to 2024
$2.5MRegulation of Bile Duct Growth in Bile Duct Ligated RatsR01DK062975 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2005 to 2014
$1.9MRole of Sensory Neuropeptides in the Regulation of Biliary FunctionR01DK076898 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2008 to 2016
$1.8MTOWARD THE OPTIMAL TIMING OF INITIATION OF DIALYSISR01DK058411 · NIDDK · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CHERTOW, GLENN MATTHEW · 2001 to 2003
$1.8MNovel biomarkers as a clinical tool for excessive alcohol use screeningR01AA025208 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIANGPUNSAKUL, SUTHAT, TU, WANZHU · 2016 to 2020
$1.7MThe Role of Stem Cell Derived Microvesicles in Cholestatic Liver InjuryR01DK107310 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2015 to 2019
$1.7MMechanisms of mast cell/cholangiocyte regulation of non-alcoholic fatty liver disease progressionR01DK119421 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI FRANCIS, HEATHER L · 2019 to 2022
$1.4MSestrin3 in the pathogenesis of alcoholic and non-alcoholic fatty liver diseaseR01DK107682 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DONG, X. CHARLIE, LIANGPUNSAKUL, SUTHAT · 2016 to 2019
$1.4MNeuroendocrine Regulation of Biliary Growth and FibrosisR01DK110035 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2017 to 2020
$1.2MImmunological Profiles and prognostic outcomes in patients with alcoholic hepatitisU01AA026917 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIANGPUNSAKUL, SUTHAT · 2018 to 2022
$1.2MRegulation of biliary growth and fibrosis by melatoninR01DK115184 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2017 to 2020
$1.2MBLRD VA I01 BX000574BLRD VA I01 BX001724BLRD VA I01 BX003031BLRD VA IK6 BX004601BLRD VA IK6 BX005226NIAAA NIH HHS R01 AA025208NIAAA NIH HHS R21 AA025157NIAAA NIH HHS R21 AA025997NIAAA NIH HHS U01 AA026917NIAAA NIH HHS UH2 AA026903NIDDK NIH HHS R01 DK054811NIDDK NIH HHS R01 DK058411NIDDK NIH HHS R01 DK062975NIDDK NIH HHS R01 DK076898NIDDK NIH HHS R01 DK107310NIDDK NIH HHS R01 DK107682NIDDK NIH HHS R01 DK108959NIDDK NIH HHS R01 DK110035NIDDK NIH HHS R01 DK115184NIDDK NIH HHS R01 DK119421NIDDK NIH HHS T32 DK007698
Abstract
BACKGROUND AND
aimsApelin (APLN) is the endogenous ligand of its G protein-coupled receptor, apelin receptor (APJ). APLN serum levels are increased in human liver diseases. We evaluated whether the APLN-APJ axis regulates ductular reaction and liver fibrosis during cholestasis. APPROACH AND
resultsWe measured the expression of APLN and APJ and serum APLN levels in human primary sclerosing cholangitis (PSC) samples. Following bile duct ligation (BDL) or sham surgery, male wild-type (WT) mice were treated with ML221 (APJ antagonist) or saline for 1 week. WT and APLN
conclusionsThe APLN-APJ axis induces cholangiocyte proliferation through Nox4/ROS/ERK-dependent signaling and HSC activation through intracellular ROS. Modulation of the APLN-APJ axis may be important for managing cholangiopathies.
Indexed as
AcetylcysteineAnimalsApelinApelin ReceptorsCell ProliferationCholangitis, SclerosingCholestasisEnzyme InhibitorsExtracellular Signal-Regulated MAP KinasesFlavonoidsFree Radical ScavengersHepatic Stellate CellsHumansLiver CirrhosisMiceNADPH Oxidase 42-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoateAcetylcysteineApelinApelin ReceptorsAPLN protein, humanApln protein, mouseAplnr protein, mouseEnzyme InhibitorsExtracellular Signal-Regulated MAP KinasesFlavonoidsFree Radical ScavengersNADPH Oxidase 4NitrobenzoatesPyransReactive Oxygen Species
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