Evidence map›Paper›PMID 32964407›Full record

ArticleJournal of neurovirology2020

Elevated serum substance P during simian varicella virus infection in rhesus macaques: implications for chronic inflammation and adverse cerebrovascular events.

Andrew N Bubak, Vicki Traina-Dorge, Christina N Como, Brittany Feia, Catherine M Pearce, Laura Doyle-Meyers, Arpita Das, Jayme Looper, Ravi Mahalingam, Maria A Nagel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Andrew N BubakDepartment of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.
Vicki Traina-DorgeMicrobiology Division, Tulane National Primate Research Center, Tulane University, Covington, LA, 70433, USA.
Christina N ComoDepartment of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.
Brittany FeiaDepartment of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.
Catherine M PearceDepartment of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.
Laura Doyle-MeyersMicrobiology Division, Tulane National Primate Research Center, Tulane University, Covington, LA, 70433, USA.
Arpita DasMicrobiology Division, Tulane National Primate Research Center, Tulane University, Covington, LA, 70433, USA.
Jayme LooperDepartment of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge, LA, 70803, USA.
Ravi MahalingamDepartment of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.
Maria A NagelDepartment of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA. maria.nagel@cuanschutz.edu.ORCID 0000-0003-0549-812X
University of Colorado Denver · USTulane University · USLouisiana State University · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
ZCM:A NOVEL BROAD-SPECTRUM MICROBICIDE FOR SEXUALLY TRANSMITTED INFECTIONSP51RR000164 · NCRR · TULANE UNIVERSITY OF LOUISIANA · PI VEAZEY, RONALD S. · 1985 to 2011
$100.1M
VARICELLA ZOSTER VIRUS VASCULOPATHY: CHANGING CLINICAL PRACTICEP01AG032958 · NIA · UNIVERSITY OF COLORADO DENVER · PI NAGEL, MARIA ACENA · 2009 to 2023
$30.3M
Neurobiology of Varicella Zoster VirusR01NS093716 · NINDS · UNIVERSITY OF COLORADO DENVER · PI COHRS, RANDALL J. · 2015 to 2019
$2.2M
National Institutes of Health (US) P51 RR00164NCRR NIH HHS P51 RR000164NIA NIH HHS P01 AG032958NIH HHS P51 OD011104NINDS NIH HHS R01 NS093716
6 · The paper itself

Abstract

Varicella and zoster, produced by varicella-zoster virus (VZV), are associated with an increased risk of stroke that may be due to persistent inflammation and hypercoagulability. Because substance P is associated with inflammation, hypercoagulability, and atherosclerotic plaque rupture that may contribute to increased stroke risk after VZV infection, we measured serum substance P in simian varicella virus-infected rhesus macaques. We found significantly increased and persistent serum substance P concentrations during varicella and zoster compared with pre-inoculation, supporting the hypothesis that VZV-induced increases in serum substance P may contribute to increased stroke risk associated with VZV infection.

Indexed as

AnimalsBiomarkersGene ExpressionHerpesvirus 3, HumanImmunosuppressive AgentsInflammationMacaca mulattaMaleRiskStrokeSubstance PTacrolimusVaricella Zoster Virus InfectionVirus ActivationWhole-Body IrradiationBiomarkersImmunosuppressive AgentsSubstance PTacrolimusSimian varicella virusStrokeSubstance PVaricellaZoster

Identifiers

PMID32964407
PMCPMC7718397
OpenAlexW3088584405

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.