ArticleMolecular and cellular biochemistry2021
The anticarcinogen activity of β-arbutin on MCF-7 cells: Stimulation of apoptosis through estrogen receptor-α signal pathway, inflammation and genotoxicity.
Article in Molecular and cellular biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Ethnopharmacological and Antiaging Evaluation of Salvia cadmica: Modulation of MMP1/MMP3 and Collagen in Oxidative Stress-Induced Senescence.Chemistry & biodiversity · 2026Article
- Arbutin-A Hydroquinone Glycoside: Journey from Food Supplement to Cutting-Edge Medicine.Chinese journal of integrative medicine · 2026Review
- Ultrasound-assisted aqueous extract of Campanula macrostachya enhances fibroblast repair via antioxidant and cytokine-modulatory mechanisms.Protoplasma · 2026Article
- 3,3'-Di-O-methylellagic Acid Isolated fromPharmaceuticals (Basel, Switzerland) · 2026Article
- Exploring the Anticancer, Anti-Inflammatory, and Antibiofilm Efficacy of Endemic Stachys longiflora: Insights into the Phytochemical Composition.ChemistryOpen · 2025Article
- Study on the In Vitro and In Vivo Antioxidant Activity and Potential Mechanism ofAntioxidants (Basel, Switzerland) · 2025Article
- Role of arbutin in the inhibition of FBXO5 in hepatocellular carcinoma.Discover oncology · 2024Article
- Research progress on the anti-tumor effects of euphorbia humifusa.Discover oncology · 2024Review
- Heterocyclic phytometabolites formononetin and arbutin preventToxicology reports · 2024Article
- Double-Edged Sword Effect of Diet and Nutrition on Carcinogenic Molecular Pathways in Breast Cancer.International journal of molecular sciences · 2024Review
- Structure-activity relationship of anticancer drug candidate quinones.Turkish journal of chemistry · 2024Article
- Arbutin overcomes tumor immune tolerance by inhibiting tumor programmed cell death-ligand 1 expression.International journal of medical sciences · 2024Article
- Comprehensive phytochemical analysis of lingonberry (RSC advances · 2023Article
- Arbutin: Occurrence in Plants, and Its Potential as an Anticancer Agent.Molecules (Basel, Switzerland) · 2022Review
- Revealing the Phenolic Acids inMetabolites · 2022Article
- Phytochemical characterization and bioactivity toward breast cancer cells of unhydrolyzed and acid-hydrolyzed extracts ofNatural product communications · 2022Article
- Arbutin improves gut development and serum lipidsFrontiers in nutrition · 2022Article
- Recent Progress on Feasible Strategies for Arbutin Production.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arbutin is one of the active ingredients employed in cosmetics as a skin whitening agent. In the present study, the possible effects of arbutin on breast cancer were determined with human breast adenocarcinoma (MCF-7) cells. α and β-arbutin cytotoxicity levels in MCF-7 cells were determined with the MTT method. At low (1-10 mM) doses, α-arbutin appears to be more toxic than β-arbutin. At higher (5-200 mM) and LD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.