ReviewHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2020
Insulin Resistance the Hinge Between Hypertension and Type 2 Diabetes.
Review in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
128 citing papers in PubMed, 4 syntheses or guidelines pooled it, 202 citations in OpenAlex.
- Diagnostic and prognostic value of triglyceride glucose index: a comprehensive evaluation of meta-analysis.Cardiovascular diabetology · 2024Pooled it
- Prevalence and risk factors for type 2 diabetes mellitus in women with gestational diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Geriatric sarcopenia is associated with hypertension: A systematic review and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2023Pooled it
- Association Between Triglyceride-Glucose Index and Hypertension: A Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Insulin Resistance and Blood Pressure Control on Cognitive Outcomes.Hypertension (Dallas, Tex. : 1979) · 2026Trial
- Trial
- Postprandial Responses to a Standardised Meal in Hypertension: The Mediatory Role of Visceral Fat Mass.Nutrients · 2022Trial
- Nine anthropometric insulin resistance indices predict mortality and life expectancy across glucose states.iScience · 2026Article
- Functional Connections Between Insulin and Neurotrophin-3 in Hemodialysis Patients with Type 2 Diabetes.Current issues in molecular biology · 2026Review
- Association of the TyG-related indices with hypertension-diabetes comorbidity in middle-aged and older adults: a suburban community-based study.BMC cardiovascular disorders · 2026Article
- METEOR: a data-adaptive Mendelian randomization method for powerful detection of shared and specific exposures underlying multiple outcomes.Briefings in bioinformatics · 2026Article
- Causal effects among hypertension, osteoporosis, and metabolites: A Mendelian randomization study.Journal of the Chinese Medical Association : JCMA · 2026Article
- Hyperinsulinaemia as a cause of obesity and cardiometabolic diseases.Nature reviews. Endocrinology · 2026Review
- Expression of APOL1 and NOTCH2 genes in patients with type 2 diabetes mellitus attending babcock University Teaching Hospital, Ogun State, Nigeria.Scientific reports · 2026Article
- Comparative Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists on Composite Surrogate Markers of Insulin Resistance: A Real-World Study Using METS-IR and SPISE.Journal of clinical medicine · 2026Article
- Gut hormones in POTS and their relation to hemodynamic parameters and gastrointestinal symptoms.Scientific reports · 2026Article
- Article
- Association between changes in systolic blood pressure and the incidence of diabetes mellitus: a retrospective study based on the Korean National Health Screening Cohort.Korean journal of family medicine · 2026Article
- Clinical Use of the Triglycerides/Glucose (TyG) Index in the Early Assessment of Metabolic Alterations and Cardiovascular Remodeling in Essential Hypertensive Patients.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Triglyceride-glucose index as a biochemical predictor of hypertension in patients with type 2 diabetes and prediabetes: Evidence from the NHANES database.Journal of medical biochemistry · 2026Article
68 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies have documented a high incidence of diabetes in hypertensive patients.Insulin resistance is defined as a less than expected biologic response to a given concentration of the hormone and plays a pivotal role in the pathogenesis of diabetes. However, over the last decades, it became evident that insulin resistance is not merely a metabolic abnormality, but is a complex and multifaceted syndrome that can also affect blood pressure homeostasis. The dysregulation of neuro-humoral and neuro-immune systems is involved in the pathophysiology of both insulin resistance and hypertension. These mechanisms induce a chronic low grade of inflammation that interferes with insulin signalling transduction. Molecular abnormalities associated with insulin resistance include the defects of insulin receptor structure, number, binding affinity, and/or signalling capacity. For instance, hyperglycaemia impairs insulin signalling through the generation of reactive oxygen species, which abrogate insulin-induced tyrosine autophosphorylation of the insulin receptor. Additional mechanisms have been described as responsible for the inhibition of insulin signalling, including proteasome-mediated degradation of insulin receptor substrate 1/2, phosphatase-mediated dephosphorylation and kinase-mediated serine/threonine phosphorylation of both insulin receptor and insulin receptor substrates. Insulin resistance plays a key role also in the pathogenesis and progression of hypertension-induced target organ damage, like left ventricular hypertrophy, atherosclerosis and chronic kidney disease. Altogether these abnormalities significantly contribute to the increase the risk of developing type 2 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.