Evidence map›Paper›PMID 32964311›Full record

ArticleClinical oral investigations2021

The role of M1 and M2 macrophage polarization in progression of medication-related osteonecrosis of the jaw.

Polytimi Paschalidi, Ioannis Gkouveris, Akrivoula Soundia, Evangelos Kalfarentzos, Emmanouil Vardas, Maria Georgaki, Georgios Kostakis, Boban M Erovic, Sotirios Tetradis, Christos Perisanidis and 1 more

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In one paragraph

Article in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 38 citations in OpenAlex.

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  13. Etiopathogenesis of medication-related osteonecrosis of the jaws: a review.Journal of molecular medicine (Berlin, Germany) · 2024
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  20. Immune Dysfunction in Medication-Related Osteonecrosis of the Jaw.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Polytimi PaschalidiDepartment of Oral and Maxillofacial Surgery, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, Goudi, Athens, Greece. polina_paschal@hotmail.com.ORCID http://orcid.org/0000-0003-1777-4312
Ioannis GkouverisDepartment of Oral Medicine and Pathology, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, Goudi, Athens, Greece.
Akrivoula SoundiaDivision of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, 90095, USA.
Evangelos KalfarentzosDepartment of Oral and Maxillofacial Surgery, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, Goudi, Athens, Greece.
Emmanouil VardasClinic of Hospital Dentistry, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, Goudi, Athens, Greece.
Maria GeorgakiDepartment of Oral Medicine and Pathology, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, Goudi, Athens, Greece.
Georgios KostakisDepartment of Oral and Maxillofacial Surgery, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, Goudi, Athens, Greece.
Boban M ErovicInstitute of Head and Neck Diseases, Evangelical Hospital Vienna, Hans-Sachs Gasse 10-12, 1180, Vienna, Austria.
Sotirios Tetradis *Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, 90095, USA.
Christos Perisanidis *Department of Oral and Maxillofacial Surgery, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, Goudi, Athens, Greece.
Nikolaos G Nikitakis *Department of Oral Medicine and Pathology, School of Dentistry, National and Kapodistrian University of Athens, Thivon 2, Goudi, Athens, Greece.
National and Kapodistrian University of Athens · GRUniversity of California, Los Angeles · US

Funding

Pathophysiologic Mechanisms of Bisphosphonate Related Osteonecrosis of the JawsR01DE019465 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TETRADIS, SOTIRIOS · 2009 to 2024
$5.4M
NIDCR NIH HHS R01 DE019465
6 · The paper itself

Abstract

objectivesThe aim of this study was to investigate the relationship between M1 and M2 macrophage polarization and clinical stage in patients with medication-related osteonecrosis of the jaw (MRONJ) who underwent treatment with bisphosphonates or denosumab. MATERIALS AND

methodsM1 and M2 macrophage density and expression of interleukin (IL)-6 and IL-10 were assessed on biopsies of mucosal tissues surrounding necrotic bone in 30 MRONJ patients with stages 1-3 and controls. For identification of M1 and M2 macrophages, double CD68/iNOS and CD68/CD206 immunofluorescence staining was conducted, respectively. Computer-assisted immunofluorescence quantification of markers was performed.

resultsEarly stage 1 MRONJ patients showed a switch toward the M2 phenotype, as indicated by the higher density of M2 macrophages, the decreased M1/M2 ratio, and the upregulation of IL-10. MRONJ patients with advanced stages 2 and 3 showed a shift toward M1-polarized macrophages, as suggested by the higher density of M1 macrophages, the increased M1/M2 ratio, and the overexpression of IL-6. The macrophage density of both M1 and M2 subsets was significantly enhanced in patients receiving bisphosphonates compared with those receiving denosumab.

conclusionsThe M1-M2 macrophage polarization status in mucosal tissues bordering necrotic bone correlates with clinical stage of MRONJ. Patients with early-stage MRONJ show a switch toward M2-polarized macrophages, while MRONJ patients with advanced stage demonstrate a shift toward the M1 phenotype. CLINICAL RELEVANCE: Therapeutic molecules targeting the inflammatory microenvironment via the regulation of either M1 or M2 macrophage polarization may represent a novel strategy for treatment of MRONJ.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawCell CountDiphosphonatesHumansMacrophagesDiphosphonatesAlendronateBisphosphonate-associated osteonecrosis of the jawDenosumabJaw diseasesMacrophagePhenotypeZoledronic acid

Identifiers

PMID32964311
PMCPMC7982347
OpenAlexW3088280875

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.