Evidence map›Paper›PMID 32964285›Full record

ArticlePflugers Archiv : European journal of physiology2020

TRPM7 channel activity in Jurkat T lymphocytes during magnesium depletion and loading: implications for divalent metal entry and cytotoxicity.

Alayna Mellott, Jananie Rockwood, Tetyana Zhelay, Charles Tuan Luu, Taku Kaitsuka, J Ashot Kozak

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. PRL-1/2 phosphatases control TRPM7 magnesium-dependent function to regulate cellular bioenergetics.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Alayna MellottDepartment of Neuroscience, Cell Biology and Physiology, Boonshoft School of Medicine and College of Science and Mathematics, Wright State University, Dayton, OH, 45435, USA.
Jananie RockwoodDepartment of Neuroscience, Cell Biology and Physiology, Boonshoft School of Medicine and College of Science and Mathematics, Wright State University, Dayton, OH, 45435, USA.
Tetyana ZhelayDepartment of Neuroscience, Cell Biology and Physiology, Boonshoft School of Medicine and College of Science and Mathematics, Wright State University, Dayton, OH, 45435, USA.
Charles Tuan LuuDepartment of Neuroscience, Cell Biology and Physiology, Boonshoft School of Medicine and College of Science and Mathematics, Wright State University, Dayton, OH, 45435, USA.
Taku KaitsukaSchool of Pharmacy in Fukuoka, International University of Health and Welfare, Enokizu 137-1, Okawa, Fukuoka, Japan.
J Ashot KozakDepartment of Neuroscience, Cell Biology and Physiology, Boonshoft School of Medicine and College of Science and Mathematics, Wright State University, Dayton, OH, 45435, USA. juliusz.kozak@wright.edu.
Wright State University · USFukuoka International University · JP

Funding

TRPM7 and Cellular pHR01AI114804 · NIAID · WRIGHT STATE UNIVERSITY · PI KOZAK, JULIUSZ ASHOT · 2015 to 2019
$1.8M
NIAID NIH HHS 1R01AI114804NIAID NIH HHS R01 AI114804
6 · The paper itself

Abstract

TRPM7 is a cation channel-protein kinase highly expressed in T lymphocytes and other immune cells. It has been proposed to constitute a cellular entry pathway for Mg

Indexed as

1-NaphthylamineAction PotentialsHumansInhibitory Concentration 50Ion TransportJurkat CellsMagnesiumMetals, HeavyProtein Serine-Threonine KinasesTRPM Cation Channels1-NaphthylamineMagnesiumMetals, HeavyProtein Serine-Threonine Kinases(R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamineTRPM7 protein, humanTRPM Cation ChannelsAmilorideCadmiumHAP1 cellsImmunotoxicityLanthanumMetal toxicityNS8593

Identifiers

PMID32964285
PMCPMC7561021
OpenAlexW3087926814

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.