Evidence map›Paper›PMID 32964250›Full record

ArticleSurgery today2021

Enhanced patterns on intraoperative contrast-enhanced ultrasonography predict outcomes after curative liver resection in patients with hepatocellular carcinoma.

Ikuo Nakamura, Etsuro Hatano, Masaharu Tada, Yusuke Kawabata, Shinjiro Tamagawa, Ami Kurimoto, Hideaki Iwama, Kan Toriguchi, Hideaki Sueoka, Kenjiro Iida and 3 more

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Article in Surgery today, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Ikuo NakamuraDepartment of Gastroenterological Surgery, Hyogo College of Medicine, Hyogo, Japan.
Etsuro HatanoDepartment of Gastroenterological Surgery, Hyogo College of Medicine, Hyogo, Japan. shatano@hyo-med.ac.jp.
Masaharu TadaDepartment of Gastroenterological Surgery, Hyogo College of Medicine, Hyogo, Japan.
Yusuke KawabataDepartment of Gastroenterological Surgery, Hyogo College of Medicine, Hyogo, Japan.
Shinjiro TamagawaDepartment of Gastroenterological Surgery, Hyogo College of Medicine, Hyogo, Japan.
Ami KurimotoDepartment of Gastroenterological Surgery, Hyogo College of Medicine, Hyogo, Japan.
Hideaki IwamaDepartment of Gastroenterological Surgery, Hyogo College of Medicine, Hyogo, Japan.
Kan ToriguchiDepartment of Gastroenterological Surgery, Hyogo College of Medicine, Hyogo, Japan.
Hideaki SueokaDepartment of Gastroenterological Surgery, Hyogo College of Medicine, Hyogo, Japan.
Kenjiro IidaDepartment of Gastroenterological Surgery, Hyogo College of Medicine, Hyogo, Japan.
Masahiro YoshidaUltrasound Imaging Center, Hyogo College of Medicine, Hyogo, Japan.
Takashi NishimuraDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.
Hiroko IijimaDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.
Hyogo Medical University · JP

Funding

Grant-in-Aid for Researchers, Hyogo College of Medicine, 2012 2012-005
6 · The paper itself

Abstract

purposeThis study aimed to clarify what hepatocellular carcinoma (HCC) phenotype, as categorized by intraoperative contrast-enhanced ultrasonography (CEUS), showed a high risk of recurrence after hepatic resection.

methodsPatients who underwent initial curative hepatectomy with intraoperative CEUS for a single HCC nodule were retrospectively assigned to three patterns of fine (FI), vascular (VA), and irregular (IR) according to the maximum intensity projection pattern based on intraoperative CEUS. Staining was performed for Ki-67, pyruvate kinase type M2 (PKM2), and vascular endothelial growth factor (VEGF) to assess the tumor proliferative activity, tumor glucose metabolism, and angiogenesis, respectively.

resultsOf 116 patients, 18, 50, and 48 were assigned to the FI, VA and IR patterns, respectively. IR patients demonstrated a significantly worse prognosis for both the recurrence-free survival (RFS) and overall survival (OS) (P = 0.0002, 0.0262, respectively) than did patients with other patterns. A multivariate analysis revealed an IR pattern in intraoperative CEUS to be an independent predictive factor for a poor RFS, and major hepatectomy and an IR pattern were independent predictive factors for a poor OS. An IR pattern was closely related to the tumor size (≥ 3.3 cm) and poor histological differentiation and showed a high Ki-67 index, low VEGF expression, and high PKM2 expression.

conclusionIR-pattern HCCs as classified by intraoperative CEUS may be associated with a higher risk of recurrence and worse outcomes in HCC patients after hepatic resection than other patterns.

Indexed as

Carcinoma, HepatocellularCarrier ProteinsFemaleGene ExpressionHepatectomyHumansImage EnhancementIntraoperative PeriodKi-67 AntigenLiver NeoplasmsMaleMembrane ProteinsNeoplasm Recurrence, LocalRetrospective StudiesRiskThyroid Hormone-Binding ProteinsCarrier ProteinsKi-67 AntigenMembrane ProteinsThyroid Hormone-Binding ProteinsThyroid HormonesVascular Endothelial Growth Factor AVEGFA protein, humanHepatocellular carcinomaIntraoperative contrast-enhanced ultrasonographyLiver resection

Identifiers

PMID32964250
OpenAlexW3088742380

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.