Evidence map›Paper›PMID 32964138›Full record

ArticleNPJ digital medicine2020

CheXaid: deep learning assistance for physician diagnosis of tuberculosis using chest x-rays in patients with HIV.

Pranav Rajpurkar, Chloe O'Connell, Amit Schechter, Nishit Asnani, Jason Li, Amirhossein Kiani, Robyn L Ball, Marc Mendelson, Gary Maartens, Daniël J van Hoving and 4 more

Open access · goldAbstract read
In one paragraph

Article in NPJ digital medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 6 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 6 syntheses or guidelines pooled it, 134 citations in OpenAlex.

  1. Pooled it
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  4. eHealth in TB clinical management.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022
    Pooled it
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  7. Review
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  14. Three Challenges for AI-Assisted Decision-Making.Perspectives on psychological science : a journal of the Association for Psychological Science · 2024
    Article
  15. Article
  16. For Tuberculosis, Not "To Screen or Not to Screen?" but "Who?" and "How?"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Pranav Rajpurkar *Stanford University Department of Computer Science, Stanford, CA USA.ORCID 0000-0002-8030-3727
Chloe O'Connell *Massachusetts General Hospital Department of Anesthesia, Boston, MA USA.
Amit Schechter *Stanford University Department of Computer Science, Stanford, CA USA.
Nishit AsnaniStanford University Department of Computer Science, Stanford, CA USA.
Jason LiStanford University Department of Computer Science, Stanford, CA USA.
Amirhossein KianiStanford University Department of Computer Science, Stanford, CA USA.ORCID 0000-0003-4471-477X
Robyn L BallStanford University AIMI Center, Stanford, CA USA.ORCID 0000-0002-7335-3339
Marc MendelsonDepartment of Medicine, University of Cape Town, Cape Town, South Africa.
Gary MaartensDepartment of Medicine, University of Cape Town, Cape Town, South Africa.
Daniël J van HovingDepartment of Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-4300-0372
Rulan GrieselDepartment of Medicine, University of Cape Town, Cape Town, South Africa.
Andrew Y NgStanford University Department of Computer Science, Stanford, CA USA.
Tom H BoylesDepartment of Medicine, University of Cape Town, Cape Town, South Africa.
Matthew P LungrenStanford University AIMI Center, Stanford, CA USA.
Stanford University · USUniversity of Cape Town · ZAStanford Medicine · USMassachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) is the leading cause of preventable death in HIV-positive patients, and yet often remains undiagnosed and untreated. Chest x-ray is often used to assist in diagnosis, yet this presents additional challenges due to atypical radiographic presentation and radiologist shortages in regions where co-infection is most common. We developed a deep learning algorithm to diagnose TB using clinical information and chest x-ray images from 677 HIV-positive patients with suspected TB from two hospitals in South Africa. We then sought to determine whether the algorithm could assist clinicians in the diagnosis of TB in HIV-positive patients as a web-based diagnostic assistant. Use of the algorithm resulted in a modest but statistically significant improvement in clinician accuracy (

Indexed as

DiagnosisMachine learning

Identifiers

PMID32964138
PMCPMC7481246
OpenAlexW3084346490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.