Evidence map›Paper›PMID 32964075›Full record

ArticleBone reports2020

Bone phenotype in melanocortin 2 receptor-deficient mice.

Tsuyoshi Sato, Takanori Iwata, Michihiko Usui, Shoichiro Kokabu, Yasutaka Sugamori, Yuki Takaku, Takashi Kobayashi, Ko Ito, Masahito Matsumoto, Shu Takeda and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. A rare homozygous variant ofFrontiers in endocrinology · 2023
    Article
  6. Independent Skeletal Actions of Pituitary Hormones.Endocrinology and metabolism (Seoul, Korea) · 2022
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Tsuyoshi SatoDepartment of Oral and Maxillofacial Surgery, Saitama Medical University, Saitama, Japan.
Takanori IwataDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Michihiko UsuiDivision of Periodontology, Department of Cardiology and Periodontology, Kyushu Dental University, Fukuoka, Japan.
Shoichiro KokabuDivision of Molecular Signaling and Biochemistry, Department of Health Promotion, Kyushu Dental University, Kokurakita-ku, Kitakyushu, Fukuoka, Japan.
Yasutaka SugamoriDepartment of Oral and Maxillofacial Surgery, Saitama Medical University, Saitama, Japan.
Yuki TakakuDepartment of Oral and Maxillofacial Surgery, Saitama Medical University, Saitama, Japan.
Takashi KobayashiDepartment of Oral and Maxillofacial Surgery, Saitama Medical University, Saitama, Japan.
Ko ItoDepartment of Oral and Maxillofacial Surgery, Saitama Medical University, Saitama, Japan.
Masahito MatsumotoDepartment of Biofunction Research, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
Shu TakedaDepartment of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
Ren XuState Key Laboratory of Cellular Stress Biology, School of Medicine, Xiamen University, Xiamen, China.
Dai ChidaDepartment of Oral and Maxillofacial Surgery, Saitama Medical University, Saitama, Japan.
Saitama Medical University · JPKyushu Dental University · JPTokyo Medical and Dental University · JPSanBio (Japan) · JPToranomon Hospital · JPXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considering that stress condition associated with osteoporosis, the hypothalamic-pituitary-adrenal (HPA) axis, which is essential for central stress response system, is implicated in regulating bone mass accrual. Melanocortin 2 receptor (MC2R), the receptor of adrenocorticotropic hormone is expressed in both adrenal gland cells and bone cells. To elucidate the role of HPA axis in bone metabolism, we assessed the skeletal phenotype of MC2R deficient mice (

Indexed as

ACTH, adrenocorticotropic hormoneBone metabolismFGD, familial glucocorticoid deficiencyGCs, GlucocorticoidsHPA axis, hypothalamic-pituitary-adrenal axisHSD, hydroxysteroid dehydrogenaseHypothalamic-pituitary-adrenal axisMC2R, melanocortin 2 receptorMelanocortin 2 receptorOsteocalcin

Identifiers

PMID32964075
PMCPMC7490991
OpenAlexW3081912022

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.