Evidence map›Paper›PMID 32964011›Full record

ArticleInternational journal of genomics2020

Clinical Evaluation of the Diagnostic Role of MicroRNA-155 in Breast Cancer.

Fatemeh Hosseini Mojahed, Amir Hossein Aalami, Vahid Pouresmaeil, Amir Amirabadi, Mahdi Qasemi Rad, Amirhossein Sahebkar

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in International journal of genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04720508 (Aberrant Expression of Circulating Micro RNA as a Biomarker for Diagnosis of Breast Cancer in Egyptian Females), which is not on this map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04720508 unknown statusnot on this mapstarted 2021, after this paper: background citation

Aberrant Expression of Circulating Micro RNA as a Biomarker for Diagnosis of Breast Cancer in Egyptian Females

TypeobservationalSponsorAssiut UniversityRan2021 to 2023Enrolled50ConditionsBreast CancerArmsblood sample collection.
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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  17. The association between OInternational journal of cardiology. Heart & vasculature · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Fatemeh Hosseini MojahedDepartment of Medical Sciences, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran.ORCID https://orcid.org/0000-0002-7118-2986
Amir Hossein AalamiDepartment of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.ORCID https://orcid.org/0000-0003-4928-254X
Vahid PouresmaeilDepartment of Biochemistry, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran.ORCID https://orcid.org/0000-0003-1023-1032
Amir AmirabadiSolid Tumors Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahdi Qasemi RadDepartment of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.ORCID https://orcid.org/0000-0002-6697-8680
Amirhossein SahebkarHalal Research Center of IRI, FDA, Tehran, Iran.ORCID https://orcid.org/0000-0002-8656-1444
Islamic Azad University, Mashhad · IRMashhad University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimBiochemical markers, including microRNAs (miRs), may facilitate the diagnosis and prognosis of breast cancer. This study was aimed at assessing serum miR-155 expression in patients with breast cancer and receptors.

methodsThis case-control study was conducted on 36 patients with breast cancer and 36 healthy individuals. After RNA extraction from the patient's serum, cDNA was synthesized. The expression of miR-155 was measured using RT-qPCR. Demographic and histochemical data were extracted from patient documents. Data were analyzed using the Statistical Package for the Social Sciences (SPSS) software.

resultsThe mean age of subjects in breast cancer and control groups was 47.64 ± 8.19 and 47.36 ± 7.52 years, respectively. The serum miR-155 expression was higher in the cancer group (1.68 ± 0.66) compared to the control group (

conclusionThe findings of this study revealed that serum miR-155 may serve as a potential noninvasive molecular biomarker for breast cancer diagnosis and can help predict the grade of the disease.

Identifiers

PMID32964011
PMCPMC7495225
OpenAlexW3083772719

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.