ArticleERJ open research2020
Clinical manifestations and epidemiology of adolescent tuberculosis in Ukraine.
Article in ERJ open research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Systematic review of health and disease in Ukrainian children highlights poor child health and challenges for those treating refugees.Acta paediatrica (Oslo, Norway : 1992) · 2022Pooled it
- Adolescents and young adults with TB in a low-incidence setting.IJTLD open · 2025Article
- A High Burden of Infectious Tuberculosis Cases Among Older Children and Young Adolescents of the Female Gender in Ethiopia.Tropical medicine and infectious disease · 2025Article
- Post-TB sequelae in adolescent pulmonary TB survivors.IJTLD open · 2025Article
- Clinical features of Tibetan adolescent tuberculosis at high altitudes: a retrospective study.BMC pulmonary medicine · 2024Article
- Health and socio-demographic background of Ukrainian minors and their families in Germany - challenges for refugee medicine : A cross-sectional study from the German Network University Medicine (NUM).European journal of pediatrics · 2024Article
- Clinical standards for drug-susceptible TB in children and adolescents.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023Article
- Drug-Resistant Tuberculosis Treatment Outcomes among Children and Adolescents in Karachi, Pakistan.Tropical medicine and infectious disease · 2022Article
- Profile and treatment outcomes among young patients with tuberculosis aged 15-24 years in Faridabad district of Haryana, India.BMJ open · 2022Article
- Tuberculosis in Adolescents in Bulgaria for a Three-Year Period: 2018-2020.Children (Basel, Switzerland) · 2022Article
- Addressing the Data Gaps on Child and Adolescent Tuberculosis.Pathogens (Basel, Switzerland) · 2022Review
- The Impact of Tuberculosis on the Well-Being of Adolescents and Young Adults.Pathogens (Basel, Switzerland) · 2021Review
- Tuberculosis in Adolescents and Young Adults: Emerging Data on TB Transmission and Prevention among Vulnerable Young People.Tropical medicine and infectious disease · 2021Review
- Shedding Light on Tuberculosis Deaths in Children and Adolescents.Pediatrics · 2021Article
- Genital tuberculosis masquerading as hematometra in an adolescent girl with an acute abdomen: A case report.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundDuring adolescence, childhood and adult forms of tuberculosis (TB) overlap, resulting in diverse disease manifestations. Knowing which patient characteristics are associated with which manifestations may facilitate diagnosis and enhance understanding of TB pathophysiology.
methodsIn this cross-sectional study, we included 10-19-year-olds in Ukraine's national TB registry who started TB treatment between 2015 and 2018. Using multivariable regression, we estimated associations between patient characteristics and four presentations of TB: pleural, extrathoracic, cavitary and rifampicin-resistant (RR). We also described the epidemiology of adolescent TB in Ukraine.
resultsAmong 2491 adolescent TB cases, 88.4% were microbiologically confirmed. RR-TB was confirmed in 16.9% of new and 29.7% of recurrent cases. Of 88 HIV-infected adolescents, 59.1% were not on antiretroviral therapy at TB diagnosis. Among 10-14-year-olds, boys had more pleural disease (adjusted OR (aOR) 2.12, 95% CI: 1.08-4.37). Extrathoracic TB was associated with age 15-19 years (aOR 0.26, 95% CI: 0.18-0.37) and HIV (aOR 3.25, 95% CI: 1.55-6.61 in 10-14-year-olds; aOR 8.18, 95% CI: 3.58-17.31 in 15-19-year-olds). Cavitary TB was more common in migrants (aOR 3.53, 95% CI: 1.66-7.61) and 15-19-year-olds (aOR 4.10, 95% CI: 3.00-5.73); among 15-19-year-olds, it was inversely associated with HIV (aOR 0.32, 95% CI: 0.13-0.70). RR-TB was associated with recurrent disease (aOR 1.87, 95% CI: 1.08-3.13), urban residence (aOR 1.27, 95% CI: 1.01-1.62) and cavitation (aOR 2.98, 95% CI: 2.35-3.78).
conclusionsAge, sex, HIV and social factors impact the presentation of adolescent TB. Preventive, diagnostic and treatment activities should take these factors into consideration.
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