Evidence map›Paper›PMID 32963991›Full record

ArticleERJ open research2020

Somatotypes trajectories during adulthood and their association with COPD phenotypes.

Miguel J Divo, Marta Marin Oto, Ciro Casanova Macario, Carlos Cabrera Lopez, Juan P de-Torres, Jose Maria Marin Trigo, Craig P Hersh, Ana Ezponda Casajús, Cherie Maguire, Victor M Pinto-Plata and 6 more

Abstract read
In one paragraph

Article in ERJ open research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Genetically Predicted Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2024
    Article
  5. Article
  6. Article
  7. Reduced frequencies of Foxp3Respiratory research · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Miguel J DivoPulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-0770-7653
Marta Marin OtoPulmonary Dept, Clinica Universidad de Navarra, Pamplona, Spain.
Ciro Casanova MacarioPulmonary Dept and Research Unit, Hospital Universitario La Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
Carlos Cabrera LopezRespiratory Service, Hospital Universitario de Gran Canaria Dr. Negrin, Canary Islands, Spain.
Juan P de-TorresPulmonary Dept, Clinica Universidad de Navarra, Pamplona, Spain.
Jose Maria Marin TrigoRespiratory Service, Hospital Universitario Miguel Servet, Zaragoza, Spain.ORCID https://orcid.org/0000-0001-9096-2294
Craig P HershPulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ana Ezponda CasajúsDept of Radiology, Clinica Universidad de Navarra, Pamplona, Spain.
Cherie MaguireChanning Division of Network Medicine, Boston, MA, USA.
Victor M Pinto-PlataPulmonary and Critical Care Division, Baystate Medical Center, Springfield, MA, USA.
Francesca PolverinoAsthma and Airway Disease Research Center, University of Arizona, Tucson, NM, USA.
James C RossPulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Dawn DeMeoPulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Gorka BastarrikaDept of Radiology, Clinica Universidad de Navarra, Pamplona, Spain.
Edwin K SilvermanPulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Bartolome R CelliPulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-7266-8371

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897
6 · The paper itself

Abstract

rationaleChronic obstructive pulmonary disease (COPD) comprises distinct phenotypes, all characterised by airflow limitation.

objectivesWe hypothesised that somatotype changes - as a surrogate of adiposity - from early adulthood follow different trajectories to reach distinct phenotypes.

methodsUsing the validated Stunkard's Pictogram, 356 COPD patients chose the somatotype that best reflects their current body build and those at ages 18, 30, 40 and 50 years. An unbiased group-based trajectory modelling was used to determine somatotype trajectories. We then compared the current COPD-related clinical and phenotypic characteristics of subjects belonging to each trajectory. MEASUREMENTS AND MAIN

resultsAt 18 years of age, 88% of the participants described having a lean or medium somatotype (estimated body mass index (BMI) between 19 and 23 kg·m

conclusionsCOPD patients have distinct somatotype trajectories throughout adulthood. Those with the MOLT phenotype maintain a lean trajectory throughout life. Smoking subjects with this lean phenotype in early adulthood deserve particular attention as they seem to develop more severe COPD.

Identifiers

PMID32963991
PMCPMC7487345

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.