Evidence map›Paper›PMID 32963939›Full record

ArticleActa pharmaceutica Sinica. B2020

Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis.

Xiaowei Zhang, Ping Zhang, Lin An, Ningyuan Sun, Liying Peng, Weiwei Tang, Dingyuan Ma, Jun Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed.

  1. Article
  2. Article
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  5. Article
  6. Article
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  8. Inhibition of LDHA promotes GSDME-dependent pyroptosis by activating RIG-I-like receptor signaling.Apoptosis : an international journal on programmed cell death · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaowei ZhangState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Ping ZhangState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Lin AnState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Ningyuan SunState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Liying PengState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Weiwei TangState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Dingyuan MaDepartment of Prenatal Diagnosis, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing 210004, China.
Jun ChenState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyroptosis is a form of programmed cell death, and recently described as a new molecular mechanism of chemotherapy drugs in the treatment of tumors. Miltirone, a derivative of phenanthrene-quinone isolated from the root of

Indexed as

7-AAD, 7-aminoactinomycin DAKT, AKT serine/threonine kinase, also known as protein kinase BANOVA, analysis of varianceBAX, BCL2-associated XCas9, caspase 9CCK-8, cell counting kit-8Cell deathCRISPR, clustered regularly interspaced short palindromic repeatsDCFH-DA, dye 2,7-dichlorofluoresce diacetateDMEM, Dulbecco's modified Eagle's mediumDMSO, dimethyl sulfoxideECL, enhanced chemiluminescenceERK1/2, extracellular regulated protein kinases 1/2FBS, fetal bovine serumFITC, fluorescein isothiocyanateGAPDH, glyceraldehyde-3-phosphate dehydrogenasegRNA, guide RNAGSDMD, gasdermin DGSDMEGSDME, gasdermin EHCC, hepatocellular carcinomaH&E, hematoxylin and eosinHepa1-6Hepatocellular carcinomaHepG2HRP, horseradish peroxidaseIC50, the half maximal inhibitory concentrationIgG (H + L), immunoglobulin G (heavy chain + light chain)i.p., intraperitoneali.v., intravenousKO, knockoutLDH, lactic dehydrogenaseMEK, mitogen-activated and extracellular signal-regulated kinaseMEM, minimum essential mediumMiltironeMMP, mitochondrial membrane potentialMS, mass spectrummTOR, mammalian target of rapamycinNAC, N-acetyl cysteineNC, negative controlN-GSDME, N-terminal GSDMENMR, nuclear magnetic resonanceNS, no significancep-AKT, phosphorylated-AKTPARP, poly ADP-ribose polymerasePBS, phosphate-based bufferp-ERK1/2, phosphorylated-ERK1/2PI3K, phosphatidylinositol 3-kinasePI, propidium iodidep-MEK, phosphorylated-MEKPyroptosisRIPA, radioimmunoprecipitation assayROS, reactive oxygen speciesSDS-PAGE, sodium dodecyl sulphate-polyacrylamide gel electrophoresisSD, standard deviationTBST, Tris-buffered saline with Tween solutionTCGA, the Cancer Genome AtlasVEGF, vascular endothelial growth factor

Identifiers

PMID32963939
PMCPMC7488361

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.