Evidence map›Paper›PMID 32963605›Full record

ArticleOncology letters2020

Negative regulation between the expression levels of receptor for hyaluronic acid-mediated motility and hyaluronan leads to cell migration in pancreatic cancer.

Xiao-Bo Cheng, Shuwen Wang, Hua Yang, Hanxing Tong, Guodong Shi, Lili Wu, Jian Zhou, Lei Shi, Hongwei Li, Songtao Ren and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Xiao-Bo ChengShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, P.R. China.
Shuwen WangShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, P.R. China.
Hua YangShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, P.R. China.
Hanxing TongDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Guodong ShiShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, P.R. China.
Lili WuDepartment of Radiotherapy, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Jian ZhouShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, P.R. China.
Lei ShiShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, P.R. China.
Hongwei LiShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, P.R. China.
Songtao RenShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, P.R. China.
Yuhong ZhouDepartment of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Norihiro SatoDepartment of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807-8555, Japan.
Shanghai Public Health Clinical Center · CNFudan University · CNThe First Affiliated Hospital, Sun Yat-sen University · CNUniversity of Occupational and Environmental Health Japan · JPZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Receptor for hyaluronic acid (HA)-mediated motility (RHAMM) expression is upregulated in pancreatic ductal adenocarcinoma (PDAC). In the present study, small interfering RNA knockdown was used to investigate the regulatory mechanism and function of RHAMM in PDAC cells. Reverse transcription-quantitative PCR was used to measure the mRNA expression levels of RHAMM, hyaluronan synthases (HAS1, HAS2 and HAS3) and hyaluronidases (HYAL1, HYAL2 and HYAL3) in eight PDAC cell lines. Cell migration was assessed using a Transwell assay, while HA concentration was measured using an ELISA. The results revealed that RHAMM-knockdown significantly increased migration in two PDAC cell lines, significantly decreased migration in one cell line and did not affect migration in the other cell lines, and was positively associated with changes in HA production. There was a

Indexed as

HAHASHYALPDACRHAMM-knockdown

Identifiers

PMID32963605
PMCPMC7491089
OpenAlexW3083734819

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.