Evidence map›Paper›PMID 32963362›Full record

ArticleSpinal cord2021

The association between urine neutrophil gelatinase-associated lipocalin and UTI in people with neurogenic lower urinary tract dysfunction.

Catherine S Forster, Olivia K Lamanna, Amanda Rounds, Bruce M Sprague, Inger Ljungberg, Suzanne L Groah

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Spinal cord, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Review
  5. Review
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  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Catherine S ForsterBiomedical Research Institute, Rockville, MD, 20850, USA. forstercs@upmc.edu.ORCID 0000-0002-6233-1070
Olivia K LamannaBiomedical Research Institute, Rockville, MD, 20850, USA.
Amanda RoundsMedStar National Rehabilitation Hospital, Washington, DC, 20010, USA.
Bruce M SpragueChildren's National Hospital, Washington, DC, 20010, USA.
Inger LjungbergMedStar National Rehabilitation Hospital, Washington, DC, 20010, USA.
Suzanne L GroahMedStar National Rehabilitation Hospital, Washington, DC, 20010, USA.ORCID 0000-0003-1213-1959
Children's National · USMedStar National Rehabilitation Hospital · US

Funding

NCATS NIH HHS L30 TR001292Patient-Centered Outcomes Research Institute (PCORI) AD-1310-08215
6 · The paper itself

Abstract

STUDY

designSecondary analysis of urine samples collected from a prospective within-subject clinical trial.

objectivesDescribe the baseline variation in urine neutrophil gelatinase-associated lipocalin (uNGAL) levels in adults with neurogenic lower urinary tract dysfunction (NLUTD) and determine if uNGAL levels vary according to likelihood of having a UTI.

settingGreater Washington D.C. region.

methodsUrine samples were collected from a cohort of adults with NLUTD from a clinical trial. Samples were divided into groups of "Not UTI", "Unlikely UTI", and "Likely UTI" based on symptoms and urine culture results. uNGAL was compared between groups using Kruskal-Wallis and post hoc Dunn's test. Mixed effects logistic model was used to assess the association of uNGAL and Likely UTI.

resultsTwenty-seven participants provided a total of 104 samples. uNGAL levels were lowest for the No UTI group (n = 29; 37 ng/ml interquartile range (IQR) (15, 71)), intermediate for the Unlikely UTI group (n = 67; 95 ng/ml IQR (37, 161)) and highest for the Likely UTI group (n = 8; 187 ng/ml IQR(146, 224)). uNGAL levels were higher in those with Likely UTI compared to both Unlikely UTI (p < 0.05) and No UTI (p < 0.01). uNGAL had an association with Likely UTI (OR 1.01, 95% CI (1.00-1.02), p = 0.049).

conclusionsAdults with NLUTD have notable variation in uNGAL levels in the absence of symptoms potentially due to UTI. uNGAL levels are higher in those who are likely to have UTI have higher uNGAL levels compared to those with non-specific symptoms and/or less growth on urine culture. uNGAL may have utility as a marker of UTI in people with NLUTD. SPONSORSHIP: Patient-Centered Outcomes Research Institute (PCORI) funded this work. Bioporto provided partial salary support for SLG, IL, and OKL. NGAL ELISAs were provided by Bioporto in kind.

Indexed as

Spinal Cord InjuriesUrinary TractAdultBiomarkersHumansLipocalin-2Prospective StudiesBiomarkersLipocalin-2

Identifiers

PMID32963362
PMCPMC11702270
OpenAlexW3088244995

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.