Evidence map›Paper›PMID 32963337›Full record

ArticleMolecular psychiatry2021

Prenatal air pollution influences neurodevelopment and behavior in autism spectrum disorder by modulating mitochondrial physiology.

Richard E Frye, Janet Cakir, Shannon Rose, Leanna Delhey, Sirish C Bennuri, Marie Tippett, Stepan Melnyk, S Jill James, Raymond F Palmer, Christine Austin and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 64 citations in OpenAlex.

  1. Trial
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  8. Article
  9. Knowledge, Attitudes, and Practices Regarding Air Pollution among Medical Students.International journal of environmental research and public health · 2024
    Article
  10. Article
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  12. Article
  13. Review
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  19. Article
  20. Metabolomic Signatures of Autism Spectrum Disorder.Journal of personalized medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Richard E FryeBarrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA. rfrye@phoenixchildrens.com.ORCID http://orcid.org/0000-0003-4442-2937
Janet CakirNorth Carolina State University, Raleigh, NC, USA.
Shannon RoseArkansas Children's Research Institute, Little Rock, AR, USA.ORCID http://orcid.org/0000-0003-0595-4367
Leanna DelheyArkansas Children's Research Institute, Little Rock, AR, USA.ORCID http://orcid.org/0000-0003-1301-6952
Sirish C BennuriArkansas Children's Research Institute, Little Rock, AR, USA.
Marie TippettArkansas Children's Research Institute, Little Rock, AR, USA.
Stepan MelnykArkansas Children's Research Institute, Little Rock, AR, USA.
S Jill JamesArkansas Children's Research Institute, Little Rock, AR, USA.
Raymond F PalmerDepartment of Family and Community Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
Christine AustinDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-9966-0492
Paul CurtinDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Manish AroraDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Arkansas Children's Hospital · USIcahn School of Medicine at Mount Sinai · USBarrow Neurological Institute · USNorth Carolina State University · USThe University of Texas Health Science Center at San Antonio · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigate the role of the mitochondrion, an organelle highly sensitive to environmental agents, in the influence of prenatal air pollution exposure on neurodevelopment and behavior in 96 children with autism spectrum disorder (ASD) [45 with neurodevelopmental regression (NDR); 76% Male; mean (SD) age 10 y 9 m (3 y 9 m)]. Mitochondrial function was assessed using the Seahorse XFe96 in fresh peripheral blood mononuclear cells. Second and third trimester average and maximal daily exposure to fine air particulate matter of diameter ≤2.5 µm (PM

Indexed as

Air PollutantsAir PollutionAutism Spectrum DisorderPrenatal Exposure Delayed EffectsChildFemaleHumansLeukocytes, MononuclearMaleMaternal ExposureMitochondriaPregnancyAir Pollutants

Identifiers

PMID32963337
PMCPMC8159748
OpenAlexW3088861830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.