Evidence map›Paper›PMID 32963315›Full record

ArticleScientific reports2020

Unique repertoire of anti-carbohydrate antibodies in individual human serum.

Ralph N D Luetscher, Tanya R McKitrick, Chao Gao, Akul Y Mehta, Alyssa M McQuillan, Robert Kardish, Kayluz Frias Boligan, Xuezheng Song, Lenette Lu, Jamie Heimburg-Molinaro and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Use of Microbial Microarrays to Define Antibody Specificity.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  5. Article
  6. Profiling of Anti-glycan IgA and IgG in Oral Fluid Using a Glycan Microarray.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  7. Research progress in RBC alloimmunization.Frontiers in immunology · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Glycan-Reactive Innate-like B Cells and Developmental Checkpoints.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Article
  13. Article
  14. Serum antibody screening using glycan arrays.Chemical Society reviews · 2024
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. The Usefulness of Rare Blood Group Systems in the Risk Determination for Severe COVID-19.Pathophysiology : the official journal of the International Society for Pathophysiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Ralph N D Luetscher *Department of Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, National Center for Functional Glycomics, CLS 11087 - 3 Blackfan Circle, Boston, MA, 02115, USA.
Tanya R McKitrick *Department of Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, National Center for Functional Glycomics, CLS 11087 - 3 Blackfan Circle, Boston, MA, 02115, USA.
Chao GaoDepartment of Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, National Center for Functional Glycomics, CLS 11087 - 3 Blackfan Circle, Boston, MA, 02115, USA.
Akul Y MehtaDepartment of Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, National Center for Functional Glycomics, CLS 11087 - 3 Blackfan Circle, Boston, MA, 02115, USA.
Alyssa M McQuillanDepartment of Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, National Center for Functional Glycomics, CLS 11087 - 3 Blackfan Circle, Boston, MA, 02115, USA.
Robert KardishDepartment of Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, National Center for Functional Glycomics, CLS 11087 - 3 Blackfan Circle, Boston, MA, 02115, USA.
Kayluz Frias BoliganInstitute of Pharmacology, University of Bern, 3010, Bern, Switzerland.
Xuezheng SongDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30303, USA.
Lenette LuThe Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA.
Jamie Heimburg-MolinaroDepartment of Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, National Center for Functional Glycomics, CLS 11087 - 3 Blackfan Circle, Boston, MA, 02115, USA.
Stephan von GuntenInstitute of Pharmacology, University of Bern, 3010, Bern, Switzerland.
Galit AlterThe Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA.
Richard D CummingsDepartment of Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, National Center for Functional Glycomics, CLS 11087 - 3 Blackfan Circle, Boston, MA, 02115, USA. rcummin1@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · USHarvard University · USRagon Institute of MGH, MIT and Harvard · USUniversity of Bern · CHEmory University · US

Funding

Overall Priority Score P41GM103694 · NIGMS · EMORY UNIVERSITY · PI CUMMINGS, RICHARD D · 2013 to 2018
$6.9M
Protein-Glycan Interaction Resource at the National Center for Functional Glycomics (NCFG)R24GM137763 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RICHARD D CUMMINGS · 2020 to 2026
$5.8M
Antibody Mediated Mechanisms of Immune Modulation in TuberculosisK08AI130357 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI LU, LENETTE · 2017 to 2021
$984k
NIAID NIH HHS K08 AI130357NIGMS NIH HHS P41 GM103694NIGMS NIH HHS R24 GM137763NIH HHS P41GM103694Swiss National Science Foundation 310030_162552Swiss National Science Foundation 310030_184757
6 · The paper itself

Abstract

Humoral immunity to pathogens and other environmental challenges is paramount to maintain normal health, and individuals lacking or unable to make antibodies are at risk. Recent studies indicate that many human protective antibodies are against carbohydrate antigens; however, little is known about repertoires and individual variation of anti-carbohydrate antibodies in healthy individuals. Here we analyzed anti-carbohydrate antibody repertoires (ACARs) of 105 healthy individual adult donors, aged 20-60

Indexed as

ABO Blood-Group SystemAdultAnimalsAntibodiesAntigensCarbohydratesFemaleHumansImmunity, HumoralImmunoglobulin GImmunoglobulin MMaleMiddle AgedPolysaccharidesSerumYoung AdultABO Blood-Group SystemAntibodiesAntigensCarbohydratesImmunoglobulin GImmunoglobulin MPolysaccharides

Identifiers

PMID32963315
PMCPMC7509809
OpenAlexW3088261158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.