Evidence map›Paper›PMID 32963283›Full record

ArticleCommunications biology2020

Omental macrophages secrete chemokine ligands that promote ovarian cancer colonization of the omentum via CCR1.

Venkatesh Krishnan, Supreeti Tallapragada, Bruce Schaar, Kalika Kamat, Anita M Chanana, Yue Zhang, Sonia Patel, Vinita Parkash, Carrie Rinker-Schaeffer, Ann K Folkins and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 91 citations in OpenAlex.

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  15. Two Faces of Greater Omentum.Comprehensive physiology · 2025
    Review
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Venkatesh KrishnanDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Stanford School of Medicine, Stanford Cancer Institute, Stanford, CA, USA.
Supreeti TallapragadaDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Stanford School of Medicine, Stanford Cancer Institute, Stanford, CA, USA.
Bruce SchaarGenome Technology Center, Stanford, CA, USA.
Kalika KamatDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Stanford School of Medicine, Stanford Cancer Institute, Stanford, CA, USA.
Anita M ChananaDepartment of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Yue ZhangDepartment of Physiology and Chemistry, Genentech, San Francisco, CA, USA.
Sonia PatelDepartment of Thoracic Head and Neck Medical Oncology, Division of Cancer Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Vinita ParkashDepartment of Pathology, Yale School of Medicine and Yale School of Public Health, New Haven, CT, USA.
Carrie Rinker-SchaefferDepartment of Surgery, Division of Urology, University of Chicago, Chicago, IL, USA.
Ann K FolkinsDepartment of Pathology, Stanford School of Medicine, Stanford, CA, USA.
Erinn B RankinDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Stanford School of Medicine, Stanford Cancer Institute, Stanford, CA, USA.
Oliver DorigoDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Stanford School of Medicine, Stanford Cancer Institute, Stanford, CA, USA. odorigo@stanford.edu.ORCID http://orcid.org/0000-0002-1976-5201
Stanford Cancer InstituteStanford Medicine · USThe University of Texas Health Science Center at Houston · USUniversity of California, Los Angeles · USUniversity of Chicago · USYale University · US

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4M
6 · The paper itself

Abstract

The omentum is the most common site of ovarian cancer metastasis. Immune cell clusters called milky spots are found throughout the omentum. It is however unknown if these immune cells contribute to ovarian cancer metastasis. Here we report that omental macrophages promote the migration and colonization of ovarian cancer cells to the omentum through the secretion of chemokine ligands that interact with chemokine receptor 1 (CCR1). We found that depletion of macrophages reduces ovarian cancer colonization of the omentum. RNA-sequencing of macrophages isolated from mouse omentum and mesenteric adipose tissue revealed a specific enrichment of chemokine ligand CCL6 in omental macrophages. CCL6 and the human homolog CCL23 were both necessary and sufficient to promote ovarian cancer migration by activating ERK1/2 and PI3K pathways. Importantly, inhibition of CCR1 reduced ovarian cancer colonization. These findings demonstrate a critical mechanism of omental macrophage induced colonization by ovarian cancer cells via CCR1 signaling.

Indexed as

AnimalsCell Line, TumorChemokinesChemokines, CCCRISPR-Associated Protein 9CRISPR-Cas SystemsFemaleFlow CytometryGene EditingGene Knockdown TechniquesHumansMacrophagesMiceMice, Inbred C57BLNeoplasm TransplantationOmentumCcl6 protein, mouseCcr1 protein, mouseChemokinesChemokines, CCCRISPR-Associated Protein 9Receptors, CCR1

Identifiers

PMID32963283
PMCPMC7508838
OpenAlexW3088513709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.