ArticleScientific reports2020
Dorsolateral prefrontal cortex-based control with an implanted brain-computer interface.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02224469 (Utrecht Neural Prosthesis), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Utrecht Neural Prosthesis (UNP): A Pilot Study on Controllability of Brain Signals and Application in locked-in Patients
Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Implanted brain-computer interface functionality during nighttime in late-stage amyotrophic lateral sclerosis.Scientific reports · 2026Article
- Invasive Brain-Computer Interface for Communication: A Scoping Review.Brain sciences · 2025Review
- Signal acquisition of brain-computer interfaces: A medical-engineering crossover perspective review.Fundamental research · 2025Review
- Intracortical brain-computer interfaces in primates: a review and outlook.Biomedical engineering letters · 2023Review
- Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Review
- Locked-in syndrome revisited.Therapeutic advances in neurological disorders · 2023Review
- Noninvasively recorded high-gamma signals improve synchrony of force feedback in a novel neurorehabilitation brain-machine interface for brain injury.Journal of neural engineering · 2022Article
- The Influence of Frequency Bands and Brain Region on ECoG-Based BMI Learning Performance.Sensors (Basel, Switzerland) · 2021Article
- Virtual Reality for Neurorehabilitation and Cognitive Enhancement.Brain sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
The objective of this study was to test the feasibility of using the dorsolateral prefrontal cortex as a signal source for brain-computer interface control in people with severe motor impairment. We implanted two individuals with locked-in syndrome with a chronic brain-computer interface designed to restore independent communication. The implanted system (Utrecht NeuroProsthesis) included electrode strips placed subdurally over the dorsolateral prefrontal cortex. In both participants, counting backwards activated the dorsolateral prefrontal cortex consistently over the course of 47 and 22 months, respectively. Moreover, both participants were able to use this signal to control a cursor in one dimension, with average accuracy scores of 78 ± 9% (standard deviation) and 71 ± 11% (chance level: 50%), respectively. Brain-computer interface control based on dorsolateral prefrontal cortex activity is feasible in people with locked-in syndrome and may become of relevance for those unable to use sensorimotor signals for control.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.