Evidence map›Paper›PMID 32963272›Full record

ArticleScientific reports2020

Regulation of degenerative spheroids after injury.

Yu Yong, Kanchana Gamage, Courtny Cushman, Anthony Spano, Christopher Deppmann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Axonal spheroids in neurodegeneration.Molecular and cellular neurosciences · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yu YongDepartment of Biology, University of Virginia, Charlottesville, VA, 22904-4328, USA.
Kanchana GamageAmgen, Massachusetts and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA.
Courtny CushmanDepartment of Neuroscience and Biomedical Engineering, University of Virginia, Charlottesville, VA, 22904-4328, USA.
Anthony SpanoDepartment of Biology, University of Virginia, Charlottesville, VA, 22904-4328, USA.
Christopher DeppmannDepartment of Biology, University of Virginia, Charlottesville, VA, 22904-4328, USA. deppmann@virginia.edu.
University of Virginia · USAmgen (United States) · US

Funding

Extrinsic Mechanisms Governing Injury-Induced Axon DegenerationR01NS091617 · NINDS · UNIVERSITY OF VIRGINIA · PI DEPPMANN, CHRISTOPHER D · 2015 to 2025
$4.0M
Tunable White Light Laser Confocal/Spectral Imaging MicroscopyS10RR025616 · NCRR · UNIVERSITY OF VIRGINIA · PI PERIASAMY, AMMASI · 2009 to 2009
$500k
NCRR NIH HHS S10 RR025616NINDS NIH HHS R01 NS091617NINDS NIH HHS R01NS091617
6 · The paper itself

Abstract

Neuronal injury leads to rapid, programmed disintegration of axons distal to the site of lesion. Much like other forms of axon degeneration (e.g. developmental pruning, toxic insult from neurodegenerative disorder), Wallerian degeneration associated with injury is preceded by spheroid formation along axons. The mechanisms by which injury leads to formation of spheroids and whether these spheroids have a functional role in degeneration remain elusive. Here, using neonatal mouse primary sympathetic neurons, we investigate the roles of players previously implicated in the progression of Wallerian degeneration in injury-induced spheroid formation. We find that intra-axonal calcium flux is accompanied by actin-Rho dependent growth of calcium rich axonal spheroids that eventually rupture, releasing material to the extracellular space prior to catastrophic axon degeneration. Importantly, after injury, Sarm1

Indexed as

AnimalsArmadillo Domain ProteinsAxonsAxotomyCalciumCytoskeletal ProteinsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNeurodegenerative DiseasesNeuronsReceptors, Tumor Necrosis FactorSpheroids, CellularArmadillo Domain ProteinsCalciumCytoskeletal ProteinsNerve Tissue ProteinsReceptors, Tumor Necrosis FactorSARM1 protein, mouseTnfrsf21 protein, mouseWld protein, mouse

Identifiers

PMID32963272
PMCPMC7508847
OpenAlexW3088410470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.