Evidence map›Paper›PMID 32963231›Full record

SynthesisNature communications2020

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.

Edith Hofer, Gennady V Roshchupkin, Hieab H H Adams, Maria J Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola J Armstrong, Claudia L Satizabal and 90 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

100 authors.

Edith Hofer *Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Gennady V Roshchupkin *Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3403-2313
Hieab H H Adams *Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-3687-2508
Maria J KnolDepartment of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Honghuang LinSection of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3043-3942
Shuo LiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2331-2448
Habil ZareGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, USA.
Shahzad AhmadDepartment of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-8658-3790
Nicola J ArmstrongMathematics and Statistics, Murdoch University, Perth, Australia.
Claudia L SatizabalGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, USA.
Manon BernardHospital for Sick Children, Toronto, ON, Canada.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.
Nathan A GillespieVirginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA, USA.ORCID http://orcid.org/0000-0001-8655-2823
Michelle LucianoCentre for Cognitive Epidemiology and Cognitive Ageing, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-7306-3008
Aniket MishraUniversity of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, Bordeaux, France.ORCID http://orcid.org/0000-0002-8141-1543
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-4059-1779
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-8309-094X
Rui XiaInstitute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
Xueqiu JianInstitute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
Thomas H MosleyDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Yasaman SabaGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
Lukas PirpamerClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.ORCID http://orcid.org/0000-0002-4390-9703
Stephan SeilerImaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology, University of California-Davis, Davis, CA, USA.
James T BeckerDepartments of Psychiatry, Neurology, and Psychology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-4425-4726
Owen CarmichaelPennington Biomedical Research Center, Baton Rouge, LA, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0001-7191-1723
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.
Oscar L LopezDepartments of Psychiatry, Neurology, and Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Najaf AminDepartment of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Sven J van der LeeDepartment of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3658-1375
Jayandra J HimaliDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1391-9481
Pauline MaillardImaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology, University of California-Davis, Davis, CA, USA.
Alexa S BeiserDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Charles DeCarliImaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology, University of California-Davis, Davis, CA, USA.
Sherif KaramaMcGill University, Montreal Neurological Institute, Montreal, QC, Canada.
Lindsay LewisMcGill University, Montreal Neurological Institute, Montreal, QC, Canada.
Mat HarrisCentre for Cognitive Epidemiology and Cognitive Ageing, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-1135-4141
Mark E BastinCentre for Cognitive Epidemiology and Cognitive Ageing, University of Edinburgh, Edinburgh, UK.
Ian J DearyCentre for Cognitive Epidemiology and Cognitive Ageing, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-1733-263X
A Veronica WitteDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.ORCID http://orcid.org/0000-0001-9054-6688
Frauke BeyerDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Markus LoefflerInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Karen A MatherCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
Peter R SchofieldNeuroscience Research Australia, Sydney, Australia.ORCID http://orcid.org/0000-0003-2967-9662
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
John B KwokSchool of Medical Sciences, University of New South Wales, Sydney, Australia.
Margaret J WrightQueensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia.ORCID http://orcid.org/0000-0001-7133-4970
David AmesNational Ageing Research Institute, Royal Melbourne Hospital, Parkvill, VIC, Australia.
Julian TrollorCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.ORCID http://orcid.org/0000-0002-7685-2977
Jiyang JiangCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.ORCID http://orcid.org/0000-0002-2147-6302
Henry BrodatyCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.ORCID http://orcid.org/0000-0001-9487-6617
Wei WenCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.ORCID http://orcid.org/0000-0003-2753-3870
Meike W VernooijDepartment of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Albert HofmanDepartment of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
André G UitterlindenDepartment of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7276-3387
Wiro J NiessenDepartment of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Katharina WittfeldGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-4383-5043
Robin BülowInstitute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-1884-5784
Uwe VölkerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-5689-3448
Zdenka PausovaHospital for Sick Children, Toronto, ON, Canada.
G Bruce PikeDepartments of Radiology and Clinial Neurosciences, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0001-8924-683X
Sophie MaingaultInstitut des Maladies Neurodégénratives UMR5293, CEA, CNRS, University of Bordeaux, Bordeaux, France.
Fabrice CrivelloInstitut des Maladies Neurodégénratives UMR5293, CEA, CNRS, University of Bordeaux, Bordeaux, France.ORCID http://orcid.org/0000-0001-6950-984X
Christophe TzourioUniversity of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, Bordeaux, France.
Philippe AmouyelCentre Hospitalier Universitaire de Bordeaux, France; Inserm U1167, Lille, France.ORCID http://orcid.org/0000-0001-9088-234X
Bernard MazoyerInstitut des Maladies Neurodégénratives UMR5293, CEA, CNRS, University of Bordeaux, Bordeaux, France.ORCID http://orcid.org/0000-0003-0970-2837
Michael C NealeVirginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Carol E FranzDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-8987-1755
Michael J LyonsDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
Matthew S PanizzonDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Ole A AndreassenNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-4461-3568
Anders M DaleDepartments of Radiology and Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Mark LogueDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Katrina L GrasbyPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0001-8539-0228
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4401-8950
Jodie N PainterPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0002-4992-2458
Lucía Colodro-CondePsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0002-9004-364X
Janita BraltenDepartment of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands.
Derrek P HibarImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Penelope A LindPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0002-3887-2598
Fabrizio PizzagalliImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4582-0224
Jason L SteinDepartment of Genetics & UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-4829-0513
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Sarah E MedlandPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-1382-380X
ENIGMA consortium
Perminder S SachdevCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.ORCID http://orcid.org/0000-0002-9595-3220
William S KremenDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Joanna M WardlawCentre for Cognitive Epidemiology and Cognitive Ageing, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9812-6642
Arno VillringerDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-2374-9204
Hans J GrabeGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-3684-4208
William T LongstrethDepartments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA.
Myriam FornageInstitute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0677-8158
Tomas PausBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.
Stephanie DebetteDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8675-7968
M Arfan IkramDepartment of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Helena SchmidtGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
Reinhold SchmidtClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria. reinhold.schmidt@medunigraz.at.
Sudha SeshadriGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, USA. suseshad@bu.edu.

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
THE FRAMINGHAM HEART STUDYN01HC25195 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2007 to 2014
$83.8M
Timing of Menopausal Hormone Therapy across Perimenopause to Menopause Transition: Neuroimmune System in BrainP01AG026572 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROBERTA EILEEN BRINTON · 2006 to 2026
$53.7M
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
Building on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
MRI, Genetics &Cognitive Precursors of AD &DementiaR01AG016495 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 1999 to 2016
$12.5M
Biotechnology and Biological Sciences Research Council BB/F019394/1CIHR NET54015CIHR NRF86678CIHR TMH109788Medical Research Council 8200Medical Research Council G0700704Medical Research Council G0700704/84698Medical Research Council G0701120Medical Research Council G1001245Medical Research Council G1001401Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MR/K026992/1Medical Research Council MR/M01311/1Medical Research Council MR/M013111/1Medical Research Council MR/N027558/1Medical Research Council MR/R024065/1NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01HC25195NHLBI NIH HHS N01HC55222NHLBI NIH HHS N01HC85079NHLBI NIH HHS N01HC85080NHLBI NIH HHS N01HC85081NHLBI NIH HHS N01HC85082NHLBI NIH HHS N01HC85083NHLBI NIH HHS N01HC85086NHLBI NIH HHS N02 HL64278NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS RC2 HL102419NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS P01 AG026572NIA NIH HHS P30 AG010129NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG033040NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG049607NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG059874NIA NIH HHS RF1 AG041915NIA NIH HHS RF1 AG051710NIA NIH HHS U01 AG049505NIBIB NIH HHS P41 EB015922NIBIB NIH HHS R01 EB015611NIBIB NIH HHS U54 EB020403NIH HHS S10 OD023696NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117601NINDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS087541
6 · The paper itself

Abstract

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.

Indexed as

BrainGenome-Wide Association StudyAdultAgedAged, 80 and overAgingChromosome StructuresCognitionFemaleGenomicsHumansMaleMental DisordersMiddle AgedNeurodegenerative DiseasesPhenotype

Identifiers

PMID32963231
PMCPMC7508833

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.