Evidence map›Paper›PMID 32963156›Full record

ArticleInternal medicine (Tokyo, Japan)2021

The Cytokine Expression in Patients with Cardiac Complication after Immune Checkpoint Inhibitor Therapy.

Toshihiro Tsuruda, Naoki Yoshikawa, Motoaki Kai, Masashi Yamaguchi, Reiko Toida, Tsuyoshi Kodama, Kei Kajihara, Takayuki Kawabata, Takeshi Nakamura, Koji Sakata and 6 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  5. Article
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  7. Review
  8. Modeling immune checkpoint inhibitor associated myocarditisJournal of molecular and cellular cardiology plus · 2024
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
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  17. [Research Progress of Immune Checkpoint Inhibitor-associated Myocarditis].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2021
    Article
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  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Toshihiro TsurudaDepartment of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Japan.
Naoki YoshikawaDepartment of Pharmacy, University of Miyazaki Hospital, Japan.
Motoaki KaiDepartment of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Japan.
Masashi YamaguchiDepartment of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Japan.
Reiko ToidaDepartment of Cardiology, Chiyoda Hospital, Japan.
Tsuyoshi KodamaDepartment of Respiratory Medicine, Chiyoda Hospital, Japan.
Kei KajiharaDepartment of Otolaryngology, Head & Neck Surgery, Faculty of Medicine, University of Miyazaki, Japan.
Takayuki KawabataDepartment of Otolaryngology, Head & Neck Surgery, Faculty of Medicine, University of Miyazaki, Japan.
Takeshi NakamuraDepartment of Otolaryngology, Head & Neck Surgery, Faculty of Medicine, University of Miyazaki, Japan.
Koji SakataDepartment of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Japan.
Kinta HatakeyamaDepartment of Pathology, National Cerebral and Cardiovascular Center, Japan.
Toshihiro GiDepartment of Pathology, Faculty of Medicine, University of Miyazaki, Japan.
Yujiro AsadaDepartment of Pathology, Faculty of Medicine, University of Miyazaki, Japan.
Tetsuya TonoDepartment of Otolaryngology, Head & Neck Surgery, Faculty of Medicine, University of Miyazaki, Japan.
Kazuo KitamuraDepartment of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Japan.
Ryuji IkedaDepartment of Pharmacy, University of Miyazaki Hospital, Japan.
University of Miyazaki · JPNational Sanyo Hospital · JPUniversity of Miyazaki Hospital · JPNational Cerebral and Cardiovascular Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report the cytokine expression at different stages for three patients who developed cardiac complications after immune checkpoint inhibitor (ICI) therapy. Case 1 with biopsy-proven myocarditis showed increased levels of interleukin (IL)-8, monocyte chemotactic and activating factor, and granulocyte macrophage colony-stimulating factor (GM-CSF) when he developed Takotsubo cardiomyopathy. Case 2 with subclinical myocarditis showed predominant activation of IL-8 during the progressive clinical course. Case 3 with cytokine-releasing syndrome showed substantial activations of IL-6, IL-8, GM-CSF, and interferon-γ. Our data suggest the development of unique cytokine activation in individual patients with cardiac complications after ICI therapy.

Indexed as

CytokinesImmune Checkpoint InhibitorsGranulocyte-Macrophage Colony-Stimulating FactorHumansInterferon-gammaMaleMonocytesCytokinesGranulocyte-Macrophage Colony-Stimulating FactorImmune Checkpoint InhibitorsInterferon-gammacancercytokine releasing syndromemyocarditistroponin

Identifiers

PMID32963156
PMCPMC7925267
OpenAlexW3087635138

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.