Evidence map›Paper›PMID 32963032›Full record

ArticleMolecular & cellular proteomics : MCP2020

Global Proteome and Phosphoproteome Characterization of Sepsis-induced Kidney Injury.

Yi-Han Lin, Maryann P Platt, Haiyan Fu, Yuan Gui, Yanlin Wang, Norberto Gonzalez-Juarbe, Dong Zhou, Yanbao Yu

Open access · hybridAbstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. A Protein Corona-Based Diagnostic Tool for Eroded Atherosclerotic Plaques.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  6. Article
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  8. Proteome characterization of liver-kidney comorbidity after microbial sepsis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yi-Han LinInfectious Diseases and Genomic Medicine Group, J. Craig Venter Institute, Rockville, Maryland.
Maryann P PlattInfectious Diseases and Genomic Medicine Group, J. Craig Venter Institute, Rockville, Maryland.
Haiyan FuDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Yuan GuiDivision of Nephrology, Department of Medicine, University of Connecticut School of medicine, Farmington, Connecticut.
Yanlin WangDivision of Nephrology, Department of Medicine, University of Connecticut School of medicine, Farmington, Connecticut.
Norberto Gonzalez-JuarbeInfectious Diseases and Genomic Medicine Group, J. Craig Venter Institute, Rockville, Maryland. Electronic address: NGonzale@jcvi.org.
Dong ZhouDivision of Nephrology, Department of Medicine, University of Connecticut School of medicine, Farmington, Connecticut; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address: dzhou@uchc.edu.
Yanbao YuInfectious Diseases and Genomic Medicine Group, J. Craig Venter Institute, Rockville, Maryland. Electronic address: yayu@jcvi.org.
J. Craig Venter Institute · USUniversity of Connecticut · USUniversity of Pittsburgh · US

Funding

Cellular and Molecular Mechanisms of Renal FibrosisR01DK095835 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI WANG, YANLIN · 2012 to 2021
$3.2M
Early and Transient Activation of Fibroblasts Promotes Tubule Repair after Acute Kidney InjuryK01DK116816 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHOU, DONG · 2019 to 2021
$509k
Targeting histone deacetylase 3 for chronic kidney diseaseI01BX002650 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI YANLIN WANG · 2016 to 2026
–
BLRD VA I01 BX002650NIDDK NIH HHS K01 DK116816NIDDK NIH HHS R01 DK095835
6 · The paper itself

Abstract

Sepsis-induced acute kidney injury (S-AKI) is the most common complication in hospitalized and critically ill patients, highlighted by a rapid decline of kidney function occurring a few hours or days after sepsis onset. Systemic inflammation elicited by microbial infections is believed to lead to kidney damage under immunocompromised conditions. However, although AKI has been recognized as a disease with long-term sequelae, partly because of the associated higher risk of chronic kidney disease (CKD), the understanding of kidney pathophysiology at the molecular level and the global view of dynamic regulations

Indexed as

Acute Kidney InjuryAnimalsBiomarkersCecumDisease ProgressionInflammationKidneyKineticsLigationMaleMice, Inbred C57BLPhosphoproteinsProteomeProteomicsPuncturesPyroptosisBiomarkersPhosphoproteinsProteomeacute kidney infectionbiomarker: diagnosticchronic kidney diseaseinfectious diseasekidney diseaselabel-free quantitationmass spectrometryomicsphosphoproteomeQuantificationsystems biology

Identifiers

PMID32963032
PMCPMC7710145
OpenAlexW3088455929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.