Trial reportJournal of cardiothoracic and vascular anesthesia2021
Intraoperative Remifentanil Infusion and Postoperative Pain Outcomes After Cardiac Surgery-Results from Secondary Analysis of a Randomized, Open-Label Clinical Trial.
Trial report in Journal of cardiothoracic and vascular anesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Incidence and risk factors of persistent postoperative pain after cardiac surgery: a systematic review and meta-analysis.BMC anesthesiology · 2026Pooled it
- Non-Linear Association Between Intraoperative Remifentanil Infusion and Postoperative Opioid Consumption After Uniportal VATS: A Propensity-Matched Retrospective Cohort Study.Journal of pain research · 2026Article
- Predisposing Factors for Chronic Post-Surgical Pain After Thoracic Surgery: A Scoping Review with Quantitative Synthesis.Journal of pain research · 2026Review
- Modeling drug retention as memory effects in obese patients using fractional and augmented models.Scientific reports · 2025Article
- Comparison of Propofol and Sevoflurane Anaesthesia in Terms of Postoperative Nausea-Vomiting Complication in Cardiac Surgery Patients Undergoing Enhanced Recovery After Surgery Protocol: A Prospective Randomized Study.Turkish journal of anaesthesiology and reanimation · 2024Article
- Efficacy and safety of flurbiprofen‑axetil combined with nalbuphine pretreatment on remifentanil‑induced postoperative hyperalgesia: A randomized clinical trial.Experimental and therapeutic medicine · 2023Article
- Evaluation of the Effect of New Multimodal Analgesia Regimen for Cardiac Surgery: A Prospective, Randomized Controlled, Single-Center Clinical Study [Response to Letter].Drug design, development and therapy · 2023Article
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5 authors.
Funding
Abstract
designReport of secondary pain outcomes from a prospective, randomized, open-label clinical trial that compared remifentanil and fentanyl on perioperative hyperglycemic response in cardiac surgery.
settingSingle institution, tertiary university hospital.
participantsThe study comprised 116 adult elective cardiac surgical patients.
interventionsParticipants were randomly assigned to receive either intermittent fentanyl boluses (F) or continuous remifentanil infusion (R) intraoperatively. MEASUREMENTS AND MAIN
resultsPostoperative pain was evaluated with pain scores every 6 hours for 48 hours. Pain threshold to mechanical stimuli was measured around the sternotomy incision at 48 and 96 hours. The development of chronic pain was assessed using the numeric rating scale at 1, 3, 6, and 12 months after discharge. The final analysis included 106 patients. Pain scores and wound hyperalgesia were not significantly different postoperatively between the groups. The incidence of chronic pain at 3 months was comparable in both groups (61% in group F v 58% in group R; p = 0.79). Pain of more-than-mild degree was seen in 13 (32%) patients in group F and 8 (19%) in group R (p = 0.25) at 3 months. Median pain scores were not significantly different between the groups at 1, 3, 6, and 12 months after discharge from the hospital.
conclusionsThe present study's findings suggested that intraoperative remifentanil infusion does not significantly worsen pain outcomes in patients undergoing elective cardiac surgery.
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