Evidence map›Paper›PMID 32962708›Full record

ArticleFluids and barriers of the CNS2020

Non-invasive measurement of choroid plexus apparent blood flow with arterial spin labeling.

Li Zhao, Manuel Taso, Weiying Dai, Daniel Z Press, David C Alsop

Open access · goldAbstract read
In one paragraph

Article in Fluids and barriers of the CNS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
  3. The choroid plexus water density.Magnetic resonance in medicine · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The path to leptomeningeal metastasis.Nature reviews. Cancer · 2024
    Review
  14. Article
  15. Article
  16. ChFluids and barriers of the CNS · 2024
    Article
  17. Quantification of TMagnetic resonance in medicine · 2023
    Article
  18. Article
  19. Choroid plexus perfusion and bulk cerebrospinal fluid flow across the adult lifespan.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Li ZhaoKey Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China. lz5bf@virginia.edu.ORCID http://orcid.org/0000-0003-4933-3183
Manuel TasoRadiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Weiying DaiComputer Science, State University of New York At Binghamton, Binghamton, NY, USA.
Daniel Z PressNeurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
David C AlsopRadiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Beth Israel Deaconess Medical Center · USBinghamton University · USMinistry of Education · NZ

Funding

Perfusion MRI for Multi-site Studies of Brain FunctionR01MH080729 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ALSOP, DAVID CHARLES, DETRE, JOHN A · 2007 to 2017
$3.8M
Alzheimer's Association AARF-18-566347National Institute of Mental Health (US) R01MH080729NIMH NIH HHS R01 MH080729
6 · The paper itself

Abstract

backgroundThe choroid plexus is a major contributor to the generation of cerebrospinal fluid (CSF) and the maintenance of its electrolyte and metabolite balance. Here, we sought to characterize the blood flow dynamics of the choroid plexus using arterial spin labeling (ASL) MRI to establish ASL as a non-invasive tool for choroid plexus function and disease studies.

methodsSeven healthy volunteers were imaged on a 3T MR scanner. ASL images were acquired with 12 labeling durations and post labeling delays. Regions of the choroid plexus were manually segmented on high-resolution T

resultsKinetics of the ASL signal were clearly different in the choroid plexus than in gray matter. The choroid plexus has a significantly longer T

conclusionsOur findings suggest that ASL can provide a clinically feasible option to quantify the dynamic characteristics of choroid plexus blood flow. It also provides useful reference values of the choroid plexus perfusion. The long T

Indexed as

Cerebrovascular CirculationAdultChoroid PlexusFeasibility StudiesFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingSpin LabelsSpin LabelsArterial spin labelingCerebrospinal fluidChoroid plexusMagnetic resonance imagingPerfusion

Identifiers

PMID32962708
PMCPMC7510126
OpenAlexW3089194296

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.